Altekin R.E.Caglar B.Karakas M.S.Ozel D.Deger N.Demir I.2019-08-012019-08-0120141109-9666https://hdl.handle.net/11480/752Introduction: Cirrhosis is associated with certain abnormalities in left ventricular (LV) structure and function. Two-dimensional speckle-tracking echocardiography (2D-STE) enables a rapid and accurate analysis of regional LV systolic mechanics in the longitudinal, radial and circumferential directions. The aim of this study was to precisely assess the differences among the 3 directions in the early impairment of LV myocardial contraction in non-alcoholic cirrhotic patients with preserved LV pump function.Method: A total of 75 subjects, including 38 cirrhotic patients and 37 healthy individuals, were enrolled. Using 2D-STE, the strain (S) and systolic strain rate (SR<inf>S</inf>) values belonging to the radial (R), circumferential (C), and longitudinal (L) functions of the LV were measured.Results: In the cirrhotic group, the L<inf>S</inf>(20.57 ± 2.1 vs. 28.7 ± 43.1, p<0.001) and L<inf>SR-S</inf>(1.1 ± 0.24 vs. 1.6 ± 0.3) values were found to be lower, whereas the C<inf>S</inf>(24.82 ± 2.57 vs. 19.16 ± 4.58, p<0.001) and C<inf> SRS</inf>(1.41 ± 0.3 vs. 1.2 ± 0.4, p±0.004) values were found to be higher than in the healthy control group. The R<inf>S</inf>and R<inf>SR-S</inf>values did not differ among the groups. A relationship was observed between the MELD score, which shows the severity of the disease, and the C<inf>S</inf> value (â: 0.211, p<0.01, 95%CI: 0.086-0.503).Conclusion: LV myocardial contraction was impaired in the longitudinal direction. However, LV pump function was augmented by the circumferential shortening during the ventricular systole. Using the 2D-STE method for the regional evaluation of the LV, the LV damage can be detected in the subclinical phase in cirrhotic patients. © 2014, Hellenic Cardiological Society. All rights reserved.eninfo:eu-repo/semantics/closedAccessCirrhotic cardiomyopathyStrainArticle55540241025243439