Çetin, MehmetTürk, İlterisGüven, Ebru SayılırFındık, GöktürkAydoğdu, KorayGülhan, Selim Şakir ErkmenBıçakçıoğlu, Pınar2024-11-072024-11-0720222548-0316https://doi.org/10.26663/cts.2022.023https://search.trdizin.gov.tr/tr/yayin/detay/1149915https://hdl.handle.net/11480/12477Background: In parallel with the change in circulating tumor cells, the no-touch isolation technique is offered as an option to reduce recurrences of non-small-cell lung cancer. We aimed to examine the relationship of this technique with recurrence and survival in our clinic. Materials and Methods: Among 675 patients who were operated on with the diagnosis of lung cancer between 2009 and 2015, 98 patients with tumor size of less than 3 cm in the postoperative pathology report, no visceral pleural invasion or lymph node involvement, and a negative surgical margin were included in the study. The patients were divided into two groups as patients treated with and without the no-touch isolation technique (i.e., a wedge resection group prior to lobectomy and a direct lobectomy group), and the results of recurrence and survival were evaluated statistically. Results: While adenocarcinoma was observed more frequently in the wedge resection group, squamous cell carcinoma was observed statistically more frequently among patients treated with direct lobectomy (p < 0.001). There was no statistically significant difference in recurrence or survival rates between patients treated with and without the no-touch isolation technique (p = 0.746 and p = 0.689, respectively). Conclusions: Although wedge resection before surgery is theoretically well grounded, we found that it was not clinically significant as a result of our study. The technique may prove beneficial in reevaluating chemotherapy indications based on circulating tumor cells, especially in early-stage cases where patients have not received chemotherapy, and prospective studies are needed in this regard.eninfo:eu-repo/semantics/openAccessSolunum SistemiOnkolojiBiyokimya ve Moleküler BiyolojiHücre BiyolojisiCerrahiLung cancerthoracic surgerywedge resectioncirculated tumor cellNo-touch isolation technique in early-stage non-small-cell lung cancer surgery: a retrospective studyArticle7314114610.26663/cts.2022.0231149915