Kaçanbüre, DamlaBişgin, Abdullah Taner2024-11-072024-11-0720250308-8146https://doi.org/10.1016/j.foodchem.2024.141273https://hdl.handle.net/11480/11099A novel and selective (deep eutectic solvent) DES-based microextraction method was established for the first time, utilizing a synthesized new generation High-Density Type-V DES for monitoring the dye Erythrosine (E127) in various foodstuffs and drugs. Type-V DES was created from acetophenone and diphenylamine at 3:1 M ratio. The pH, DES amount, and vortex time were optimized using Box-Behnken Design (BBD) of Response Surface Methodology (RSM). The quadratic microextraction model with R2 = 0.9982 was obtained. The limit of detection, preconcentration factor and linear dynamic range were determined to be 12 ?g/L, 50 and 41–4000 ?g/L, respectively. Effects of matrix components were examined. The developed High-Density Type-V Deep Eutectic Solvent Microextraction (HD-V-DES-ME) method was applied to foodstuffs and drugs to monitor their E127 contents and subsequently validated by applying spiked tests to real samples, with recoveries ranging between 94 and 101 %. The indexes of environmental friendliness and practicality for the method were evaluated using the Analytical GREEnness metric approach tool (AGREE) and the Blue Applicability Grade Index tool (BAGI), respectively. © 2024 Elsevier Ltdeninfo:eu-repo/semantics/closedAccessBox-Behnken design (BBD)Deep eutectic solvent V (DES(V))Erythrosine (E127)Microextraction (ME)UV–vis spectrophotometryArticle46310.1016/j.foodchem.2024.141273392780802-s2.0-85203646421Q1