Zor, Ramazan KursadErsan, SerpilKucuk, ErkutYildirim, GamzeSari, Ismail2024-11-072024-11-0720202515-8414https://doi.org/10.1177/2515841420951682https://hdl.handle.net/11480/14918Purpose: The purpose of this study was to investigate the serum levels of malondialdehyde (MDA) which is a marker of oxidative stress, monocyte chemoattractant protein-1 (MCP-1) which has an important role in inflammation, and vitamin C which has antioxidant properties in patients with wet age-related macular degeneration (wAMD). Methods: Thirty patients with wAMD were included in the study and serum levels of MDA, MCP-1, and vitamin C were compared with healthy participants (n = 30). Serum vitamin C and MDA levels were measured using a spectrophotometric method. Serum MCP-1 levels were determined by the ELISA method. Results: MCP-1 and MDA levels were higher in patients with wAMD compared with the control group (p < 0.05). Serum vitamin C levels were lower in patients with wAMD compared with the control group (p < 0.05). Conclusions: The increase in the MCP-1 levels in patients with wAMD may be associated with increased inflammation in wAMD. Decreased serum vitamin C and elevated MDA levels in patients with wAMD suggest increased oxidative stress in wAMD patients. These results indicate that the increased oxidative stress and inflammation can play a role in the pathogenesis of wAMD.eninfo:eu-repo/semantics/openAccessage-related macular degenerationchoroidal neovascularizationinflammationmalondialdehydemonocyte chemoattractant protein-1oxidative stressArticle1210.1177/2515841420951682330629292-s2.0-85104536262N/AWOS:000576394200001N/A