Seydel, Gonul SeydaGunturk, InayetYazici, CevatTopaloglu, Ulas SerkanEren, Esma EryilmazYuksel, Recep Civan2024-11-072024-11-0720242667-663Xhttps://doi.org/10.4328/ACAM.22078https://hdl.handle.net/11480/15490Aim: Overweight and obesity are substantial risk factors in the severity of COVID-19 disease. This study aimed to assess the relationship between the disease severity and leptin, adiponectin, and chemerin levels in overweight and obese COVID-19 patients. Material and Methods: The study involved 60 COVID-19 patients (patient group) and 30 healthy controls with BMI >= 25. The patient group was split into two subgroups based on disease severity (30 mild/moderate and 30 severe/critical patients). The levels of leptin, adiponectin, and chemerin in plasma were determined using the ELISA technique. Results: Our study revealed that leptin levels were considerably increased in both groups of COVID-19 patients compared to the healthy controls, while chemerin levels were decreased. In adiponectin levels, there was no statistically significant difference between the groups. Discussion: Plasma leptin and chemerin levels are associated with the progression and/or severity of disease in overweight and obese COVID-19 patients.eninfo:eu-repo/semantics/openAccessCOVID-19LeptinAdiponectinChemerinObesityArticle15532933310.4328/ACAM.22078WOS:001222910000009N/A