Altinoz E.Erdemli M.E.Gul M.Aksungur Z.Gul S.Bag H.G.Turkoz Y.2019-08-012019-08-0120181052-0295https://dx.doi.org/10.1080/10520295.2018.1519725https://hdl.handle.net/11480/1583Owing to its lipophilic property, carbon tetrachloride (CCl 4 ) is rapidly absorbed by both the liver and brain. We investigated the protective effects of crocin against brain damage caused by CCl 4 . Fifty rats were divided into five groups of ten: control, corn oil, crocin, CCl 4 and CCl 4 + crocin. CCl 4 administration decreased glutathione (GSH) and total antioxidant status (TAS) levels, and catalase (CAT) activity, while significant increases were observed in malondialdehyde (MDA) and total oxidant status (TOS) levels and superoxide dismutase (SOD) activity. The cerebral cortex nuclear lamina developed a spongy appearance, neuronal degeneration was observed in the hippocampus, and heterochromatic and pyknotic neurons with increased cytoplasmic eosinophilia were observed in the hippocampus after CCl 4 treatment. Because crocin exhibits strong antioxidant properties, crocin treatment increased GSH and TAS levels and CAT activities, and decreased MDA and TOS levels and SOD activity; significant improvements also were observed in histologic architecture. We found that crocin administration nearly eliminated CCl 4 induced brain damage by preventing oxidative stress. © 2018, © 2018 The Biological Stain Commission.eninfo:eu-repo/semantics/closedAccessBrain damagecarbon tetrachloridecatalasecrocinglutathionemalondialdehydeoxidative stressArticle93862363110.1080/10520295.2018.1519725302730722-s2.0-85054386999Q2WOS:000451027400011Q4