Disli, AliYucesoy, Esin EylemOzturk, AliDilek, Gulay2024-11-072024-11-0720231307-6175https://doi.org/10.25135/acg.oc.148.2302.2696https://hdl.handle.net/11480/15997A series of novel hybrid compounds was synthesized where 2 '-hydroxyacetophenone and N-alkylated thiotetrazole were coupled via methylene spacers of different lengths. The structures of the compounds were characterized by spectroscopic techniques, including the 1H-and 13C-NMR, FT-IR, and HRMS methods. The antimicrobial activities of the title compounds were evaluated against clinical isolates of Gram-positive and negative bacterial and fungal species. All compounds showed a broad spectrum of antimicrobial activity and inhibited all bacteria and fungi that tested with MIC values ranging from 4 to 128 mu g/ml. 4a and 5d were the most active antibacterial members.eninfo:eu-repo/semantics/openAccessHydroxyacetophenonetetrazolehybridArticle162758610.25135/acg.oc.148.2302.26962-s2.0-85165066333Q4WOS:000984238300001N/A