Aricioglu, BanuGunacar, Dilara NilKosar, TugbaCikman, Ahter SanalHatipoglu, Fatma PertekMaras, Edanur2024-11-072024-11-0720221329-19471747-4477https://doi.org/10.1111/aej.12697https://hdl.handle.net/11480/15766Fractal analysis (FA) is a quantitative, objective and non-invasive method that facilitates the characterisation of the tissue architecture. This study aims to compare the periapical healing at 1-year follow-up by evaluating newly generated trabecular bone with FA after Mineral trioxide aggregate (MTA) plug and regenerative endodontic treatment (RET). A total of 55 asymptomatic teeth with a single-canal, open apex and periapical lesion, treated with MTA plug or RET, were evaluated retrospectively. After considering the inclusion/exclusion criteria, FA was conducted on 30 periapical images using the box-counting method. In both groups, a significant decrease was observed in the periapical lesion size at 1-year follow-up (p < 0.01). However, there was no significant difference between the MTA plug and RET (p > 0.01). Significantly higher fractal dimension values were detected at 1-year follow-up in both MTA plug and RET cases (p < 0.01). However, the difference was not significant between the groups (p > 0.01). Both procedures seem to improve periapical healing with a new resistant bone of similar density and complexity.eninfo:eu-repo/semantics/closedAccessfractal analysisMTA plugperiapical bone qualityregenerative endodontic treatmentArticle48344445010.1111/aej.12697361975842-s2.0-85139195837Q2WOS:000863898700001Q4