Bayrakci, MevlutErtul, SerefYilmaz, Mustafa2019-08-012019-08-0120110021-9568https://dx.doi.org/10.1021/je2004319https://hdl.handle.net/11480/4669This study is the first report on the extraction of poorly soluble drug molecules such as nifedipine, niclosamide, and furosemide from the organic phase to the aqueous phase by water-soluble p-phosphonate calix[n]arene receptors via a liquid-liquid phase extraction process. These water-soluble calixarene derivatives were easily obtained from the reaction between their corresponding chloromethylated derivatives and trimethyl phosphite. From the liquid-liquid phase extraction studies, it was observed that the size of the p-phosphonate calix[n]arenes changed the extraction percentage of selected drug molecules.eninfo:eu-repo/semantics/closedAccessArticle56124473447910.1021/je20043192-s2.0-83455218258Q2WOS:000297608800030Q2