Ali, GhorbatNajeeb, MalikaJubrail, AmadSelamoğlu, Zeliha2024-11-072024-11-0720192148-127Xhttps://doi.org/10.24925/turjaf.v7i11.1924-1927.2893https://search.trdizin.gov.tr/tr/yayin/detay/355369https://hdl.handle.net/11480/12294?-thalassemia major is severe hemolytic anemia which requires repeated blood transfusion and forsurvival, which leading to iron overload. Serious complications due to iron over load are recognizedin the thalassemia patients. objectives Vitamin D and calcium are important factors for homeostasisof calcium in this study. This study was conducted for a period of two year including from patientswith ?- thalassemia major from Duhok Thalassemia Centre between 2014 -2015. Thirty eighth ?thalassemia major patients and thirty eighth persons with age- matched as control group wereenrolled in the study. Serum concentration of 25- hydroxy vitamin D and calcium were estimated byenzyme linked fluorescent assay and colorimetric method, respectively. In patients, the level ofserum 25- hydroxy vitamin D was significantly lower 11.11±4.36 ng/mL compared with controlgroup (14.03±5.96ng/mL). Vitamin D deficiency is observed about 94.73% in patients. The meanlevel of serum calcium in patients group is 7.9±0.47mg/dL and 8.98±0.77 mg/dL in control group.There was a statistically significant difference in serum calcium value between patients and controlgroup. 44.73% of patients have hypocalcaemia. This study demonstrated a high prevalence ofVitamin D deficiency and low total serum calcium levels in thalassemia patients with a significantlylower than healthy group. Hypocalcemia and vitamin D deficiency may be results from the negativeeffect of the repeated blood transfusion and malnourishment.eninfo:eu-repo/semantics/openAccessGenel ve Dahili TıpHematolojiOnkolojiArticle7111924192710.24925/turjaf.v7i11.1924-1927.2893355369