Akin, Dilara F.Ozkan, Didem T.Kurekci, EminAkar, Nejat2024-11-072024-11-0720181110-10672090-9268https://doi.org/10.4103/ejh.ejh_55_17https://hdl.handle.net/11480/15943Background CD95 is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in downregulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide polymorphism resulting in guanine-to-adenine (G>A) transition in the CD95 promoter region (position - 1377) is thought to reduce stimulatory protein 1 transcription factor binding and decrease CD95 expression. The purpose of this study is to examine a genetic polymorphism in the core promoter region of CD95 and to evaluate association between its frequency and clinical findings. Patients and methods G-1377A in the CD95 promoter region was genotyped by polymerase chain reaction and restriction endonuclease analysis finally were sequenced by Sanger Sequecing. Results Among 146 patients, CD95 G-1377A (rs2234767) single nucleotide polymorphism carriers frequencies have been identified as 25% (n=37) GA and AA 4% (n=6). This polymorphism of the distribution of the CD95 gene in children with acute leukemia will be a guide for future studies. Conclusion This polymorphism of the distribution of the CD95 gene in children with acute leukemia will be a guide for future studies. (c) 2018 The Egyptian Journal of Haematologyeninfo:eu-repo/semantics/closedAccessacute lymphoblastic leukemiaacute myeloblastic leukemiaCD95 polymorphismArticle432454810.4103/ejh.ejh_55_17WOS:000441639800001N/A