Sadiqa, AyeshaRasul, AzharHussain, GhulamShah, Muhammad AjmalSarfraz, IqraRiaz, AmmaraSarfraz, Ayesha2024-11-072024-11-072021978-153619608-5978-153619463-0https://hdl.handle.net/11480/11710Brain cancers are highly lethal and fatal human cancers due to various hurdles imposed by the brain's physiology and anatomy on therapeutic implications. Higher relapse rates and poor prognosis in brain cancers complicate the situation, leading to high mortalities. Therefore, it is the need of the hour to develop efficient therapeutic strategies against brain cancers. The exploitation of nutraceuticals is an emerging approach for the cure of cancers due to their safety, efficacy, and cost-effectiveness. This chapter focuses on the significance and mechanism of anti-brain cancer nutraceuticals such as juglone, formononetin, eugenol, curcumin, and biochanin. The anti-brain cancer activity of nutraceuticals is governed by the modulation of various cell signaling molecules such as apoptosis-related factors (caspase-3, caspase-9, Bax, Bid, Reactive oxygen species), cell cycle regulators (Cyclin D1, p53), protein kinases (FAK, p-ERK, p38 MAPK), enzymes (MMP-2, MMP-9), transcriptional factors (c-myc, Wnt, ?-catenin), and cytokines (TGF-?). The reported data recommend multitarget activity of nutraceuticals which might play an essential role in developing nutraceuticals to novel pharmacological drugs shortly. © 2021 Nova Science Publishers, Inc. All rights reserved.eninfo:eu-repo/semantics/closedAccessAnti-cancerBrain cancerEugenolFormononetinGlioblastomaJugloneNutraceuticalsBook Chapter3273482-s2.0-85109625888N/A