Emele, Roseline EkeA.Salim, MohammedPolat, FikriyeDiler, Songül Budak2024-11-072024-11-0720241513-7368https://doi.org/10.31557/APJCP.2024.25.6.2003https://hdl.handle.net/11480/11349Background: Inflammatory bowel diseases (IBD), Crohn’s disease (CD), and ulcerative colitis (UC) are diseases that result from the combined effects of a predisposing genetic background and several environmental factors, including smoking. Some genes can influence these diseases through genetic inheritance, and their regulation is explained by gene polymorphism. However, Toll-like receptor (TLR) genes have been identified as susceptibility genes for CD and UC. Methods: A case-control study was performed on a Turkish population composed of 105 healthy controls and 79 CD, 77 UC patients genotyped by Allele-specific PCR and PCR–RFLP for TLR9 (T-1486C) and TLR 2 (-196 to -174del) gene. Genotype and allele frequencies of TLR9 (T-1486C) and TLR 2 (-196 to -174del) gene polymorphisms compared to allele frequencies in CD and UC patients. Results: No statistically significant findings were found between the CD, UC patients, and the control group in terms of both genotype distributions and allele frequencies for TLR 9 (T-1486C; rs187084) and TLR 2 (-196 to -174del; rs111200466) gene polymorphisms in a Turkish population (P?> 0.05). Conclusion: No association was found between the TLR2 (rs111200466) and TLR 9 (rs187084) gene polymorphisms among IBD patients and the control groups in the Turkish population. © (2024), This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.eninfo:eu-repo/semantics/openAccessInflammatory Bowel DiseasesPolymorphismTLR 2 (–196 to –174del)TLR 9 (T-1486C)Article2562003201010.31557/APJCP.2024.25.6.2003389186622-s2.0-85197086511Q3