Yetisen, MehmetUslu, HasanBaltacioglu, Cem2024-11-072024-11-0720240008-40341939-019Xhttps://doi.org/10.1002/cjce.25201https://hdl.handle.net/11480/13992This research endeavour primarily aimed to optimize and establish a model for the recovery of pravastatin, a well-known statin drug recognized for its cholesterol-lowering properties, from aqueous solutions using reactive extraction. This study used the Box-Behnken design to investigate extraction parameters and create a concise model equation illustrating the relationship between variables and responses. The investigation showed a strong agreement between the model equation and experimental outcomes. It highlighted a positive correlation, demonstrating that higher concentrations of reactant and pravastatin led to notable improvements in extraction efficiency. Two out of 90 experiments had extraction efficiencies below 10%, both with constant factors except for solvent type, while 14 experiments exceeding 80% efficiency highlighted the positive impact of a 50% reactant concentration on extraction efficiency. According to a statistical second-order polynomial, the predicted extraction efficiency stands at 75.14%. In the culminating phase of the study, optimal extraction conditions were meticulously determined, resulting in the identification of an optimal set of parameters: a pravastatin concentration of 35 mg center dot L-1, an adogen concentration of 20.91% (v/v), and a butanol phase ratio of 0.2% (v/v). Under optimal conditions, the experimental extraction efficiency reached 72.69%, closely aligning with values predicted through numerical optimization employing response surface methodology.eninfo:eu-repo/semantics/closedAccessadogenBox-Behnkenoptimizationpravastatinreactive extractionArticle10272561257110.1002/cjce.252012-s2.0-85183836332Q2WOS:001152315100001N/A