Akın D.F.Aşlar-öner D.Kürekçi E.Akar N.2019-08-012019-08-0120180041-4301https://dx.doi.org/10.24953/turkjped.2018.02.005https://hdl.handle.net/11480/1741In this study we aim to determine the genotype distribution and allele frequencies of common TPMT (*2, *3A, *3B and *3C) polymorphisms in Turkish children with acute leukemia. The study population consisted of 169 patients aged between 1 and 15 years who were admitted to Losante Pediatric Hematology and Children’s Hospital with the diagnosis of acute leukemia. Genotyping of TPMT polymorphisms was screened with real-time PCR using fluorescence melting curve detection analysis. We found that the frequencies of four allelic variants of TPMT are *2 (238 G>C) (0,0%), *3A (460G>A and 719A>G) (1.7%), *3B (460G>A) (1,7%) and *3C (719A>G) (2.4%). Frequency of TPMT alleles increases the efficacy of leukemia treatment. Thus, TPMT genotyping can be useful for optimizing 6-MP therapy. © 2018, Turkish Journal of Pediatrics. All rights reserved.eninfo:eu-repo/semantics/openAccessChildhoodLeukemiaPolymorphismTPMTArticle60214715210.24953/turkjped.2018.02.005303251202-s2.0-85054890408Q3351666WOS:000447379800005Q4