The effect of intradermal administration of inactive platelet-rich plasma on flap viability in rats

Küçük Resim Yok

Tarih

2017

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Purpose: To evaluate the effect of inactive form of platelet rich plasma (PRP) on the flap viability. Methods: Thirty six rats were used. Rats were divided into six groups then 9x3 cm random pattern skin flaps were elevated from dorsum of all rats. For precluding vascularization from the base, a silicone layer was placed under the flap in groups 2(only flap+silicone), 4(saline+silicone) and 6(PRP+silicone). In groups 1(only flap), 2(only flap+silicone) nothing was done except flap surgery. In groups 3(saline) and 4(saline+silicone), saline was applied intradermally , in groups 5(PRP) and 6(PRP+silicone), inactive form of PRP which obtained from different 16 rats was applied intradermally, into certain points of flaps immediately after surgery. After 7 days flap necrosis ratio was measured in all groups. Results: Mean necrosis rate in group 5(PRP) (16.05%) was statistically significantly lower than group 1(only flap) (31,93%) and group 3(saline) (30,43%) (p<0.001). Mean necrosis rate in group 6(PRP+silicone) (36.37%) was statistically significantly lower than group 2(only flap+silicone) (47.93%) and group 4(saline+silicone) (45.65%) (p<0.001). Conclusion: Intradermal inactive platelet rich plasma administration decreases flap necrosis so for skin application. © 2017, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.

Açıklama

Anahtar Kelimeler

Platelet-Rich plasma, Rats, Skin, Surgical flaps

Kaynak

Acta Cirurgica Brasileira

WoS Q Değeri

Scopus Q Değeri

Cilt

32

Sayı

4

Künye