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  • Küçük Resim Yok
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    Affinity of Propofol to Human Serum Albumin and Cardiovascular Effects
    (2019) Özaltun, Betül; Selamoğlu, Zeliha
    Propofol genel anestezi ve sedasyonda kullanılır. Bir lipofilik ajandır ve karaciğerde aktif olmayanforma dönüştürülür, sonra idrarla atılır. Vücuttaki etkileri çözünür albüminle değişir. Propofolün%97’den fazlası serum albümine bağlanır. Böylece hipoalbunemi propofol etkilerini değiştirir.Serbest propopol formu, kan-beyin bariyeri ve kardiyak endotelin hücresel zarı gibi tüm zarlarıgeçebilir. Propofol, önemli miyokard depresyonuna neden olabilir, kan basıncını düşürebilir vehayatı tehdit eden aritmilere sebep olabilir. Uygulama dozu ve süresine bağlı olarak serbest ve bağlıpropofol ve albümin formlarındaki değişiklikler, bu oranın kardiyak profil üzerindeki etkileri buçalışmada tartışılmıştır. Bulgulara göre, propofole albümin afinitesinin tüm doz gruplarında zamanabağlı olarak azaldığı tespit edildi. Serbest albumin ve serbest propofol oranı artacağından, budurumun kalp profilini olumsuz yönde etkileyebileceği düşünülmektedir.
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    EVALUATION OF ANTIMICROBIAL ACTIVITIES AND INVITRO CYTOTOXIC ACTIVITIES OF GUNDELIA TOURNEFORTII L. PLANT EXTRACTS
    (2019) Özaltun, Betül; Daştan, Taner
    ObjectiveKenger, Gundelia tournefortii plant from Asteraceae family, is a medicinal plant. Flowers, leaves, seeds and roots of Kenger have been reported to be usedas a source of food.Material and MethodsIn this study, it was aimed to evaluate the antimicrobial and in vitro antiproliferative properties of Kenger which fresh sprouts are peeled and eated cooked or uncooked in Sivas. The water phase and essential oil extraction of the body parts of Kenger were aimed to be evaluated in terms of their antimicrobial and in vitroantiproliferative properties.ResultsCytotoxic activities were investigated using the Breast Cancer Cell Line (MCF-7) and human endothelial cell line (HUVEC). The effects of plant extracts on cellcultures were determined by the absorbance of Eliza reader by XTT method. Kenger plant extracts have been shown to have weak antimicrobial effects withMIC values. ConclusionsIn the province of Sivas, growing parts of the plant in the spring and summer are cut and peeled into the inner parts of the nutrients. Kenger, which is used in thetreatment of various diseases, has cytotoxic effects on the cells we tested and has a weak antimicrobial effect.
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    Evaluation of the effects on atherosclerosis and antioxidant and antimicrobial activities of Agaricus xanthodermus poisonous mushroom
    (2020) Özaltun, Betül; Sevindik, Mustafa
    Objectives: The aim of this study was to determine the total antioxidant capacity, total oxidant capacity,oxidative stress index and antimicrobial activity of a poisonous mushroom Agaricus xanthodermus. The effectsof mushrooms on atherosclerosis are due to their antioxidant effects.Methods: Mushroom samples collected from study field were extracted with methanol (MeOH) anddichloromethane (DCM) using soxhlet apparatus. Total antioxidant status (TAS), total oxidant status (TOS)and oxidative stress index (OSI) were measured using Rel Assay trade kits. Antimicrobial activities were testedon 9 microorganisms (Staphylococcus aureus, S. aureus MRSA, Enterococcus faecalis, Escherichia coli,Pseudomonas aeruginosa, Acinetobacter baumannii, Candida albicans, C.krusei and C. glabrata) using themodified agar dilution method.Results: In this study A. xanthodermus has shown high antioxidant and antimicrobial activities. In addition,the highest activities of MeOH and DCM extracts of the mushrooms were demonstrated against E. coli, P.aeruginosa, and A. baumannii.Conclusions: In conclusion, A. xanthodermus is considered to be a poisonous mushroom and can be used as apharmacological natural agent due to its high antioxidant and antimicrobial activities.
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    Potential Cardiogenic Effects of Poisonous Mushrooms
    (2021) Sevindik, Mustafa; Özaltun, Betül; Braidy, Nady; Akgül, Hasan; Akata, Ilgaz; Selamoğlu, Zeliha
    Natural resources have been the savior of people at every stage of human history. Mushrooms are very valuable food sources, especially in the rainy seasons. They can be grouped as poisonous, edible or inedible, depending on their nutritional status. These groups have positive or negative effects. Some types of mushrooms have different medicinal properties thanks to their bioactive compounds. It is necessary to characterize their toxicological profiles, especially before using mushroom species for human consumption, as toxic substances are identified even in some edible species. Mycetism, known as mushroom poisoning, is an international health problem. There are those that cause deadly poisoning and limited symptoms of poisoning in mushrooms. Poisonous mushrooms are divided into many classes as cytotoxic, neurotoxic, myotoxic, gastroirritan mushrooms according to their types or symptoms they cause. It is known that mushroom poisoning can cause serious toxicity on the liver, kidneys and central nervous system. However, its effect on heart function has not been determined yet. This study focused on poisonous mushrooms and their cardiological effects.