Yazar "Acar, Elif" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Clinical, histopathological and immunohistochemical evaluation of ultraviolet A1 treatment in early-stage mycosis fungoides
    (Wiley, 2024) Keskin, Nuray; Temel, Berkay; Adisen, Esra; Aksakal, Ahmet Burhan; Acar, Elif; Erdem, Oezlem
    Background/Purpose Mycosis fungoides (MF) is the most common variant of cutaneous T-cell lymphomas primarily involving the skin. Early-stage MF is characterised by non-specific skin lesions and non-diagnostic biopsies. While skin-focused treatments, such as PUVA and narrowband UVB (nbUVB), are the most frequently recommended treatments, the UVA1 efficacy has been researched in recent years. The purpose of this study was to evaluate the clinical, histopathological and immunohistochemical aspects of UVA1 treatment in patients with early-stage MF. Methods The modified severity weighted assessment scale (mSWAT) was used for total skin body scoring before and after treatment. Skin punch biopsies were taken from the patients before and after treatment. UVA1 therapy was performed five times each week. Results This study included 26 patients with early-stage MF. The total number of UVA1 sessions varied between 15 and 34. Complete response was observed in 8 (30.8%) of 26 patients (30.8%). The median mSWAT score decreased statistically significantly from 7.1 to 2.0 after treatment (p < .001). Histopathological complete response was observed in 2 (9.5%) of 21 patients. A statistically significant decrease in dermal interstitial infiltrate was observed on histopathological examination after treatment (p = .039). Epidermal CD4/CD8 levels decreased statistically significantly higher from a median of 2.5-1.2 in the complete clinical response group after treatment (p = .043). Conclusion According to our results, UVA1 treatment has an effect on early-stage MF in terms of clinical, histopathological and immunohistochemistry.
  • Küçük Resim Yok
    Öğe
    Evidence for financial hierarchy theory in capital structure decisions: Data from BIST companies
    (Bogazici Universitesi, 2020) Acar, Elif; Vural, Gamze; Çetenak, Emin Hüseyin
    The aim of this study is to test and expound the firm-level factors that determine financial leverage via testing a panel data of non-financial companies listed in the BIST throughout 1994-2015. We aim to build on our previous study of the same data set (Vural & Acar, 2018), which tested the basic model of Financial Hierarchy theory via a simple regression analysis of financial leverage on financial deficit and yielded positive results at 1% significance level. In this study, using reliably significant factors of leverage, we further analyze the effects of firm characteristics on changes in leverage by using the system version of the Generalized Method of Moments (System GMM). Operational profitability and firm size are found to negatively affect debt levels, while market-to-book value ratio has a positive effect, as predicted by the Financial Hierarchy theory. The median industrial leverage ratio has a positive coefficient, more in line with Trade-off theory's predictions. © 2020 Bogazici Universitesi. All rights reserved.
  • Küçük Resim Yok
    Öğe
    Tumor-Infiltrating Lymphocytes (TIL), Tertiary Lymphoid Structures (TLS), and Expression of PD-1, TIM-3, LAG-3 on TIL in Invasive and In Situ Ductal Breast Carcinomas and Their Relationship with Prognostic Factors
    (Cig Media Group, Lp, 2022) Acar, Elif; Esendagli, Guldal; Yazici, Ozan; Dursun, Ayse
    We wanted to evaluate the expression of immune checkpoint receptors in pathology samples to support research on whether the immune response against breast cancer can be used for treatment. For this purpose, we studied 312 invasive and 68 in situ breast cancers. We found that PD-1 and stromal TIL were associated with survival. Determination of PD-1 expression on stromal TIL can provide information about whether the patient can benefit from immunotherapy. Introduction: Immunotherapy has been determined as an important choice in breast carcinomas, especially in tumors with markedly inflammatory response. About this promising subject, tumor-infiltrating lymphocytes (TIL) and the expression of immune control point receptors on TIL have gained importance. Materials and Methods: In this study, stromal TIL and tertiary lymphoid structures (TLS) were determined in tumor tissues of 312 invasive and 68 in situ breast cancer patients. Expression rates of PD-1, LAG-3, and TIM-3 on intratumoral and stromal TIL were immunohistochemically evaluated. Results: In invasive breast carcinomas, stromal TIL was found to be significantly associated with lymph node metastasis, HR and HER2 expression, and basal-like phenotype, as the presence of TLS with neoadjuvant therapy, recurrence, death, and expression of HR and HER2. PD-1, LAG-3, and TIM-3 expressions were found to be associated with HR and HER2 status, stromal TIL rates, and TLS. In multivariate analysis, high stromal TIL and PD-1 expression in intratumoral TIL were found to be independent prognostic factors in terms of overall survival and disease-free survival. Conclusion: Evaluation of TIL and immune control point receptor expressions in breast cancer is particularly important in terms of planning the therapeutic approaches based on immunotherapy protocols.