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    Oxidative, nitrosative and glycosative stress levels in Crimean-Congo hemorrhagic fever disease
    (Bayrakol Medical Publisher, 2020) Ersan, Serpil; Bakir, Sevtap; Engin, Aynur; Bakir, Mehmet
    Aim: This study aimed to investigate Oxidative/Nitrosative/Glycosative stress (OS/NS/GS) biomarkers levels in CCHF disease, their levels in the course of the disease, and to benefit from the results obtained in the pathogenesis and treatment of the disease. Material and Methods: In the study, serum OS, NS, and GS biomarkers levels of the participants in the CCHF (n = 60) and control (n = 35) groups were compared. In addition, the participants with CCHF were classified as mild, moderate, and severe infection subgroups according to the Severity Grading Score (SGS). A commercial enzyme-linked immunosorbent test kit was used to measure the levels of 8-OHdG, 3-NT, 8-NG, NO, CML, 8-iso-PGF2a in serum samples obtained from the participants in the CCHF and control groups. MDA levels were measured in serum samples by a spectrophotometric method. Total Antioxidant Status and Total Oxidant Status levels were determined using commercial kits. Results: On the whole, the mean OS/NS/GS biomarkers levels in the participants in the CCHF group were significantly higher than were those in the control group (p <0.005). Accordingly, it was found that in the participants with CCHF, as the severity of the disease increased so did the biomarker levels. Discussion: Consequently, in addition to routine laboratory tests, the presence of unbalanced OS/NS/GS in CCHF should be taken into account in the followup of patients. Considering that the main factor in CCHF treatment is supportive therapy, adding antioxidant agents to the treatment can contribute to the improvement of the prognosis.