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Öğe Antioxidant, antimicrobial and DNA protection activities of phenolic content of Tricholoma virgatum (Fr.) P.Kumm.(Biointerface Research Applied Chemistry, 2020) Selamoglu, Zeliha; Sevindik, Mustafa; Bal, Celal; Ozaltun, Betul; Sen, Ismail; Pasdaran, ArdalanTricholoma is one of the famous genera of Basidiomycota division. Although some species of this genus have been used as culinary mushrooms, very negligible investigations have been conducted on Tricholoma genus phenolic contents and their biological activities. In the present study, the antioxidant, antimicrobial, and DNA protection properties of total phenolic contents of Tricholoma virgatum (Fr.) P. Kumm. (54% methanolic extract) were assessed. T. virgatum phenolic content was determined by an analytic high-performance liquid chromatography (HPLC) method based on compression with standard phenolic compounds including gallic acid, catechin, chlorogenic acid, epicatechin, and coumaric acid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were determined using Rel Assay kits. For DNA protective potential assay, pBR322 supercoiled DNA method was used. The antimicrobial activity assay was done based on the agar dilution method on six different microorganisms include Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, and Candida tropicalis. The total phenolic contents of this mushroom lied within range of 2.02-56.85 ppm based on coumaric acid and chlorogenic acid as standards. TAS, TOS, and OSI values were determined as 3.754 +/- 0.088 mmol/L, 8.362 +/- 0.085 mu mol/L, and 0.223 +/- 0.007, respectively. T. virgatum methanol extract could exhibit a protective effect on DNA against the hydroxyl radical at 100 mu g/mL concentration. Although T. virgatum is not recommended as an edible mushroom, according to our results, this mushroom could be considered as valuable source for phenolic compounds with significant antioxidant/antimicrobial effects.Öğe Biological Activities of Wild Poisonous Mushroom Entoloma sinuatum (Bull.) P. Kumm (Boletales)(Kahramanmaras Sutcu Imam Univ Rektorlugu, 2022) Bal, Celal; Baba, Hayri; Akata, Ilgaz; Sevindik, Mustafa; Selamoglu, Zeliha; Akgul, HasanIn many studies conducted in recent years, it has been found that the beneficial natural ingredients found in mushrooms are very important in curing various diseases and eliminating disease factors. It has been reported that fungi that spread in different countries have biological activities. In this study, antioxidant level (TAS). oxidant level (TOS), and antibacterial and antifungalactivity of Entoloma sinuatum (Bull.) P. Kumm were determined. Ethanol extract of the mushroom was extracted in a Soxhlet apparatus. Antioxidant and oxidant levels were determined using Rel Assay TAS and TOS kits. Also. antimicrobial activity was tested against bacteria l and fungal strains using the agar dilution method. As a result of the studies. the TAS value of the mushroom was determined 2.64 +/- 0.15. the TOS value vas 6.58 +/- 0.23, and the OSI (Oxidative stress index) value was 0.25 +/- 0.02. In addition, it was determined that the ethanol extract of the mushroom was effective against bacteria at 200 and 400 mu g/mL, and against fungi at 50 mu g/mL concentrations. As a result, it was determined that E. sinuatum is a natural antioxidant and antimicrobial agent.Öğe OXIDATIVE STRESS INDEX AND ANTIOXIDANT CAPACITY OF LEPISTA NUDA COLLECTED FROM GAZİANTEP/TURKEY(Yildiz Technical University, 2019) Bal, Celal; Sevındık, Mustafa; Akgul, Hasan; Selamoglu, ZelihaThe objective of the present study was to determine antioxidant capacity and oxidative stress index of Lepista nuda (Bull.) Cooke mushrooms collected in Şahinbey (Gaziantep/Turkey) using novel research kits that could conduct high sensitive and reliable measurements with in vitro analysis methods. Its antioxidant activity was determined by DPPH method and TAS (total antioxidant status), TOS (total oxidant status) and OSI (oxidative stress index) values were determined using Rel Assay kits. Study findings determined that the TAS value was 3.102 mmol/L, the TOS value was 36.920 ?mol/L and the OSI value was 1.190 for the mushroom. It was observed that the radical scavenging activity of DPPH increased in higher concentrations. It was concluded that L. nuda samples collected in regions with low TOS values could be used as better antioxidant sources. © 2019 by the Author(s).Öğe OXIDATIVE STRESS INDEX AND ANTIOXIDANT CAPACITY OF LEPISTA NUDA COLLECTED FROM GAZIANTEP/TURKEY(Yildiz Technical Univ, 2019) Bal, Celal; Sevindik, Mustafa; Akgul, Hasan; Selamoglu, ZelihaThe objective of the present study was to determine antioxidant capacity and oxidative stress index of Lepista nuda (Bull.) Cooke mushrooms collected in Sahinbey (Gaziantep/Turkey) using novel research kits that could conduct high sensitive and reliable measurements with in vitro analysis methods. Its antioxidant activity was determined by DPPH method and TAS (total antioxidant status), TOS (total oxidant status) and OSI (oxidative stress index) values were determined using Rel Assay kits. Study findings determined that the TAS value was 3.102 mmol/L, the TOS value was 36.920 mu mol/L and the OSI value was 1.190 for the mushroom. It was observed that the radical scavenging activity of DPPH increased in higher concentrations. It was concluded that L. nuda samples collected in regions with low TOS values could be used as better antioxidant sources.Öğe PHENOLIC COMPOUND AND ANTIOXIDANT POTENTIAL OF(Univ Agronomic Sciences & Veterinary Medicine Bucharest - Usamv, 2023) Ahmad, Zaheer; Ozdemir, Betul; Sevindik, Mustafa; Eraslan, Emre Cem; Selamoglu, Zeliha; Bal, CelalMushrooms have been used for both culinary and medicinal reasons for a very long time. Mushrooms are useful as both a food and a medication due to their high nutritional, protein, vitamin, and phenolic content. The current research aims to determine the antioxidant activity and phenolic content of Hebeloma sinapizans. Multiple epidemiological research looked at the possible link between polyphenol consumption and cardiovascular illness. Antioxidant, antiplatelet, antiinflammatory, antilipidemic, and antihypertensive are the categories used to classify the actions of phenolic substances. HPLC was used to isolate the phenolic compounds (HPLC). Measurements of oxidative stress, total oxidant levels, and total antioxidant levels were all calculated with the use of Rel Assay kits. The mushroom's TAS, TOS, and OSI values were measured, and its gallic acid, chlorogenic acid, and cinnamic acid concentrations were identified. Due to its high levels of phenolic compounds, H. synapizans is thought to be a source of phenolic compounds. High TAS and TOS values and low OSI values indicate that the mushroom has antioxidant potential. As a result, it has been seen that H. synapizans can be a good source of antioxidants.Öğe PHENOLIC COMPOUND AND ANTIOXIDANT POTENTIAL OF Hebeloma sinapizans MUSHROOM(University of Agronomic Sciences and Veterinary Medicine of Bucharest, 2023) Ahmad, Zaheer; Özdemir, Betül; Sevindik, Mustafa; Eraslan, Emre Cem; Selamoglu, Zeliha; Bal, CelalMushrooms have been used for both culinary and medicinal reasons for a very long time. Mushrooms are useful as both a food and a medication due to their high nutritional, protein, vitamin, and phenolic content. The current research aims to determine the antioxidant activity and phenolic content of Hebeloma sinapizans. Multiple epidemiological research looked at the possible link between polyphenol consumption and cardiovascular illness. Antioxidant, antiplatelet, antiinflammatory, antilipidemic, and antihypertensive are the categories used to classify the actions of phenolic substances. HPLC was used to isolate the phenolic compounds (HPLC). Measurements of oxidative stress, total oxidant levels, and total antioxidant levels were all calculated with the use of Rel Assay kits. The mushroom's TAS, TOS, and OSI values were measured, and its gallic acid, chlorogenic acid, and cinnamic acid concentrations were identified. Due to its high levels of phenolic compounds, H. synapizans is thought to be a source of phenolic compounds. High TAS and TOS values and low OSI values indicate that the mushroom has antioxidant potential. As a result, it has been seen that H. synapizans can be a good source of antioxidants. © 2023 The Author(s).Öğe Phenolic Contents, Oxidant/Antioxidant Potential and Heavy Metal Levels in Cyclocybe cylindracea(Assoc Pharmaceutical Teachers India, 2018) Sevindik, Mustafa; Akgul, Hasan; Bal, Celal; Selamoglu, ZelihaIntroduction: Mushroom species have been used for medical purposes and as nutrients since the old times. The present study aimed to determine phenolic content, antioxidant activity and heavy metal content of Cyclocybe cylindracea (DC.) Vizzini & Angelini mushroom. Materials and Methods: Phenolic contents were screened with HPLC devices. TAS, TOS and OSI values were determined using Rel Assay kits. Heavy metal content were determined with atomic absorption method using an atomic absorption spectrophotometer. Result and Discussion: Gallic acid, hesperidin, catechin, syringic acid and hydroxybenzoic acid were detected in the mushroom. It was determined that the heavy metal content in C. cylindracea were generally at optimal levels and the TOS value of mushroom was high. Conclusion: C. cylindracea could be consumed as a good antioxidant source as long as it is obtained from safe areas.
