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    Histological structure of Nannospalax xanthodon cochlea tissue
    (Springer, 2021) Balcioglu, Esra; Gur, Fatih Mehmet; Gur, Hatice Emel; Bilgici, Pinar; Kanklic, Teoman
    Because of the growth retardation in the eyes of Nannospalax xanthodon blind mole rat, some genetic and environmental adaptations have occurred in the smelling and hearing systems so that they can communicate efficiently in the galleries underground. This study was aimed to determine the histological and morphometric structure of the unique organization of the cochlea, which plays an important role in hearing in N. xanthodon. After the decalcification process, the cochlear tissue was cut in 5 mu m thickness after routine histological procedures. Then these sections stained with Hematoxylin & Eosin and Masson trichrome methods were examined histologically. Besides, the data obtained by taking measurements with the Image J program in the basal, media, and apex regions of the cochlea were evaluated statistically. It was observed that basilar membrane length, tectorial membrane length, stria vascularis thickness, and inner-outer hair cell lengths increased, while Reissner's membrane length and basilar membrane thickness decreased. These data show that the general histological structure of the blind mole rat cochlea is similar to that of other mammals. By evaluating histomorphological findings, it was concluded that cochlea, which plays a primary role in hearing with the effect of living conditions and genetic structures, develops better in blind mole rats than other living species.
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    Histological structure of Nannospalax xanthodon cochlea tissue (Mar,10.1007/s11756-021-00746-5, 2021)
    (Springer, 2021) Balcioglu, Esra; Gur, Fatih Mehmet; Gur, Hatice Emel; Bilgici, Pinar; Kankilic, Teoman
    A Correction to this paper has been published:
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    The effect of ionizing radiation on the fetal bone development in pregnant rats: Role of melatonin
    (Wiley, 2024) Tokpinar, Adem; Nisari, Mehtap; Yilmaz, Seher; Yay, Arzu; Yildiz, Oguz Galip; Balcioglu, Esra; Alisan, Pinar
    Radiation has been widely used in many business sectors over the last century. Our study investigated the possible teratogenic effects of radiation on the bones of rat fetuses and the protective effect of melatonin against these effects. In this study, 15 pregnant female Wistar albino rats were used. These rats were divided into four groups: the control group, melatonin group (10 mg/kg/day), radiation group (0.5 gray), radiation (0.5 gray) + melatonin group (10 mg/kg/day), and sham group (1 mm hanks/day). The skeletal system development of fetuses was examined with double skeletal and scanning electron microscope (SEM), histopathological methods. In our study, fetal weight, placental weight, and fetal morphometric values were found to be statistically significantly decreased in the radiation group compared to the control group (p < .05). In immunohistochemistry (IHC) analysis, alkaline phosphatase, and tartrate-resistant acid phosphatase) concentrations were found to be significantly lower in the radiation group compared to the other groups. In the SEM analysis, it was observed that the amount of calcium and sodium decreased when the radiation group was compared with the other groups. As a result, when exposed to ionizing radiation during pregnancy, melatonin has a protective feature against the negative effects of radiation on the bone development of fetuses.