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    Calixarene-immobilized monolithic cryogels for preparative protein chromatography
    (Elsevier B.V., 2018) Guven I.; Gezici O.; Bayrakci M.; Morbidelli M.
    New cation exchanger monolithic stationary phases were prepared by immobilization of three different calixarene derivatives (i.e. tetracarboxylate calix[4]arene, CLX-COO, tetrasulfonate calix[4]arene, CLX-SO3, and tetraphosphonate calix[4]arene, CLX-PO4) onto a monolithic cryogel support (i.e. poly(2-hydroksyethylmethacrilate-co-glycidyl methacrylate, P) and investigated with respect to preparative protein chromatography. The obtained monoliths were characterized through various techniques such as FTIR spectroscopy, isoelectric point measurements, titrimetric analyses, and mercury intrusion porosimetry. Protein retention was investigated using some model proteins (i.e. lysozyme, cytochrome c, and ?-chymotrypsinogen A, human serum albumin, and myoglobin), and the role of modifier (i.e. NaCl) concentration and pH was thoroughly analyzed under isocratic and gradient elution conditions. Overloading experiments were also conducted to study dynamic adsorption capacity and the obtained values were found to be ranging between 3 and 8 mg/mL depending on the type of calixarene molecule. Hence, higher or comparable protein adsorption capacities were seen to be applicable on calixarene-immobilized cryogels when compared to any other functionalized cryogels in the literature. Combined with the favorable properties of these monoliths, with respect to mass transport of large molecules, these results qualify calixarene functionalized monolithic cryogels as promising stationary phases for protein preparative purification. © 2018 Elsevier B.V.
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    Synthesis and spectroscopic studies of novel rhodanine azo dyes: An excellent selective chemosensor for naked-eye detecting of Cu 2+ Ion
    (2012) Ceylan A.; Baş S.Z.; Bayrakci M.; Ertul S.; Uysal A.
    This study is first report on the synthesis of novel rhodanine based azo dyes and their fluorogenic and chromogenic sensing behaviors with metal ions (Li +, Na +, K +, Rb +, Pb 2+, Ni 2+, Zn 2+, Cu 2+) by using UV-vis and fluorescence spectroscopy techniques. The results of spectroscopic experiments for rhodanine based azo dye 1a exhibited excellent selectivity for Cu 2+ over the other metal ions. Furthermore, anti-bacterial studies of rhodanine azo dyes were performed towards some selected bacteria via microbroth dilution method. Obtained results showed that rhodanine ionophore 1a showed strong antibacterial activity against S.aureus.