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    Association of IL-1Ra and IL-4 Gene VNTRs with Susceptibility to Prostate Cancer in Turkish Population
    (Allerton Press Inc, 2020) Bingol, G.; Polat, F.; Diler, S. B.
    Prostate cancer (PCa) is a very common type of cancer among men. It was revealed that Interleukin-4 (IL-4) and interleukin-1 receptor antagonist (IL-1Ra) genes had important functions such as development of prostate cells or regulating the inflammatory processes. The important role of cytokines in inflammatory mechanisms leads to the possibility that polymorphisms of these genes may contribute to the formation of prostate cancer. In this study, we aimed to investigate the association of variable number tandem repeat (VNTR) polymorphisms in the IL-1Ra and IL-4 genes with PCa in Turkish population. 70 prostate cancer patients and 110 healthy controls were involved in a case-control study. Genotype distributions and allele frequencies for the IL-1Ra intron 2 (rs2234663) and IL-4 intron 3 (rs79071878) VNTR polymorphisms were analyzed by using PCR technique. No statistically significant association was identified for both IL-1Ra intron 2 and IL-4 intron 3 polymorphisms between PCa patients and controls (P > 0.05). IL-1Ra intron 2 and IL-4 intron-3 VNTR polymorphisms were not found to be risk factors in prostate cancer and its development in Turkish population.
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    Association of IL-1Ra and IL-4 Gene VNTRs with Susceptibility to Prostate Cancer in Turkish Population (vol 54, pg 487, 2020)
    (Allerton Press Inc, 2021) Bingol, G.; Polat, F.; Diler, S. B.
    An Erratum to this paper has been published: https://doi.org/10.3103/S0095452721010060
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    Association of MYNN, TERT and TERC Gene Polymorphisms with Prostate Cancer in Turkish Population
    (Pleiades Publishing Inc, 2020) Polat, F.; Diler, S. B.; Bingol, G.
    This study aims to determine whether there is any relationship between prostate cancer development and MYNN rs10 936 599, TERC rs2 293 607 and hTERT MNS16A polymorphisms in Turkish population. The research was comprised of 77 individuals with prostate cancer and 116 healthy individuals without history of cancer. Genotyping analysis was performed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The results obtained were evaluated using the chi-square test and unconditional logistic regression analysis. In the study, the GG genotype of TERC rs2293607 polymorphism, the VNTR-243/243 genotype of TERT MNS16A polymorphism, and allele 243 were found to be statistically significant between the patient and control groups (ORc = 3.250, 95% CI = 1.176-8.980, p(c) = 0.023; ORc = 3.09, 95% CI = 1.238-7.717, p(c) = 0.016; OR = 0.638, 95% CI = 0.416-0.978, p = 0.038). On the other hand, there was no significant relationship between MYNN rs109365999 polymorphism and prostate cancer in Turkish population. In conclusion, the obtained data show that the TERC rs2293607 and TERT MNS16A VNTR-243/243 polymorphisms might be potential risk factors for the development of prostate cancer in Turkish population and might be suggested as prognostic markers.