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    Histone deacetylase inhibitory properties of metabolites from leaves of Quercus pontica K. Koch and its metabolites
    (Taylor & Francis Ltd, 2024) Renda, Gulin; Sevgi, Sezer; Soral, Michal; Bora-Akoglu, Gamze; Sari, Suat; Cetin, Ozge; Zobaroglu-Ozer, Pelin
    The infusions prepared from some Quercus L. species are used in folk medicine for medicinal purposes and consumed as tea. Quercus pontica K. Koch was selected in this study, for which no phytochemical isolation studies have been performed so far. Quercetin 3-O- beta-D-glucopyranoside, kaempferol 3-O-(6-O-galloyl)-beta-D-glucopyranoside, kaempferol 3-O-beta-D-glucopyranoside, kaempferol 3-O-(6'-coumaroyl-beta-D-glucopyranoside, phlorizin, rosmarinic acid, and catechin were isolated from the titled plant for the first time. Some polyphenolic compounds have been shown to inhibit histone deacetylase (HDAC) enzymes. However, there is no study on the any activities of Quercus species in the literature. In this study, we demonstrated that the extract has in vitro pan-HDAC inhibition activity. Through a virtual screening study, the compounds were found to inhibit HDAC7 more strongly than the other HDAC isoforms; therefore, the HDAC7 inhibition activities were studied in vitro. Kaempferol 3-O-beta-D-glucopyranoside and kaempferol 3-O-(6'-coumaroyl-beta-D-glucopyranoside) showed the best anti-HDAC7 activity with 37% and 41% inhibition at 500 mu M.
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    Split but merge: Golgi fragmentation in physiological and pathological conditions
    (Springer, 2024) Zobaroglu-Ozer, Pelin; Bora-Akoglu, Gamze
    The Golgi complex is a highly dynamic and tightly regulated cellular organelle with essential roles in the processing as well as the sorting of proteins and lipids. Its structure undergoes rapid disassembly and reassembly during normal physiological processes, including cell division, migration, polarization, differentiation, and cell death. Golgi dispersal or fragmentation also occurs in pathological conditions, such as neurodegenerative diseases, infectious diseases, congenital disorders of glycosylation diseases, and cancer. In this review, current knowledge about both structural organization and morphological alterations in the Golgi in physiological and pathological conditions is summarized together with the methodologies that help to reveal its structure.