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    Association between isolated female acne and insulin resistance: A prospective study
    (Edizioni Minerva Medica, 2016) Kartal D.; Yildiz H.; Ertaş R.; Borlu M.; Utaş S.
    Background: acne is one of the manifestations of the polycystic ovary syndrome (PCoS). Nowadays hyperinsulinemia and insulin resistance are well-known characteristics of PCoS. the aim of this study was to investigate the relation between isolated female acne and insulin resistance and to determine the effect of hyperandrogenemia in this possible relationship. METHODS: Forty ive women with acne and 24 healthy women aged 25-40 were included in the study. The global acne grading system (GAGS) was used to evaluate acne severity. Blood samples were drawn for measurements of hormone proile, basal insulin and fasting blood glucose (FBG). the oral glucose tolerance test (oGtt) was performed on another day. homeostasis model assessment (Homa) score was used to assess insulin resistance (ir). all subjects underwent abdominopelvic sonography. reSUltS: thirty-six women with acne and 24 healthy women were analyzed after exclusion. Fifteen (42%) patients had moderate acne, 11 (30%) had severe acne and 10 (28%) had very severe acne. Basal insulin, FBG, AUC glucose, AUC insulin and HOMA values were signiicantly higher in patients with acne when compared with the control group (P<0.05). after excluding patients with hyperandrogenemia, we compared the patients (N.=22) and control group with regard to ir; the serum basal insulin, aUC-insulin and aUC-glucose as well as Homa score were still signiicantly higher in patients (P<0.05). CoNClUSioNS: We concluded that there is a relationship between female acne and ir. this association is independent of hyperandrogenemia. anti-insulin drugs may an adjunctive treatment of female acne. © 2015 Edizioni Minerva Medica.
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    The effect of nebivolol on P wave duration and dispersion in patients with Behçet's disease; a prospective single-arm controlled study [Behçet hastali{dotless}gi{dotless}nda nebivololün P dalga süresi ve P dalga dispersiyonuna etkisi; prospektif, tek grup kontrollü çali{dotless}şma]
    (AVES Ibrahim Kara, 2013) Akkaya H.; Karakaş M.S.; Şahin Ö.; Borlu M.; Oguzhan A.
    Objective: Behçet's disease (BD) is a chronic multi-system disease presenting with recurrent oral and genital ulceration, and relapsing uveitis. Left ventricular diastolic dysfunction, ventricular arrhythmia and sudden cardiac death have been documented in BD. P wave dispersion (PD) has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. PD has been reported to be longer in patients with BD. Nebivolol, besides its selective beta1-blocking activity, causes an endothelium dependent vasodilatation through nitric oxide release. In this study, we searched for the effects of nebivolol on P wave duration and dispersion in patients with BD. Methods: This study was designed as prospective single-arm controlled study. We prospectively studied 35 Behçet's patients who were diagnosed according to the International Study Group criteria. Patients received 5 mg nebivolol per day for 3 months. The patients were evaluated with 12-leads electrocardiography at baseline and after for 3-month therapy. The difference between maximum and minimum P wave durations was defined as PD. The paired samples t test, Wilcoxon test were used for statistical analysis. Results: A significant decrease was observed in PD after therapy period (62.85±21.62 vs. 44.28±18.03 msec, p=0.001). No adverse effects were observed in treatment period. Conclusion: BD is associated with prolonged P wave duration and dispersion. We have shown for the first time that nebivolol causes a significant decrease in maximum P wave duration and PD in patients with BD. However, further comprehensive studies are needed to determine the long-term effects of nebivolol. © 2013 by AVES Yayi{dotless}nci{dotless}li{dotless}k Ltd.