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    Histone deacetylase inhibitory properties of metabolites from leaves of Quercus pontica K. Koch and its metabolites
    (Taylor & Francis Ltd, 2024) Renda, Gulin; Sevgi, Sezer; Soral, Michal; Bora-Akoglu, Gamze; Sari, Suat; Cetin, Ozge; Zobaroglu-Ozer, Pelin
    The infusions prepared from some Quercus L. species are used in folk medicine for medicinal purposes and consumed as tea. Quercus pontica K. Koch was selected in this study, for which no phytochemical isolation studies have been performed so far. Quercetin 3-O- beta-D-glucopyranoside, kaempferol 3-O-(6-O-galloyl)-beta-D-glucopyranoside, kaempferol 3-O-beta-D-glucopyranoside, kaempferol 3-O-(6'-coumaroyl-beta-D-glucopyranoside, phlorizin, rosmarinic acid, and catechin were isolated from the titled plant for the first time. Some polyphenolic compounds have been shown to inhibit histone deacetylase (HDAC) enzymes. However, there is no study on the any activities of Quercus species in the literature. In this study, we demonstrated that the extract has in vitro pan-HDAC inhibition activity. Through a virtual screening study, the compounds were found to inhibit HDAC7 more strongly than the other HDAC isoforms; therefore, the HDAC7 inhibition activities were studied in vitro. Kaempferol 3-O-beta-D-glucopyranoside and kaempferol 3-O-(6'-coumaroyl-beta-D-glucopyranoside) showed the best anti-HDAC7 activity with 37% and 41% inhibition at 500 mu M.
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    The optimization of growth parameters in a anodic chamber of a microbial fuel cell
    (Yildiz Technical University, 2020) Onat, Tuba Artan; Cetin, Ozge
    The pollution is a result of drastically rising fossil fuel usage due to increased global population and industrialization. Today's world needs to replace fossil fuels with new and renewable energy sources. Microbial Fuel Cells (MFCs) are devices that convert the chemical energy to direct electricity by microbial metabolic activity. Microbial growth was actualized at the anodic chamber of MFC and must be controlled carefully by microbial methods. The main aim of this study is optimizing the growth parameters of microorganisms in two-chambered MFC with optical density, dried and wet weight of microorganisms that were grown at the anode chamber of MFC. Moreover, the Chemical Oxygen Demand (COD) values of medium were determined at fed cycles of MFC. The total volume of MFC was 0.7 L and the connection was made with the salt bridge between anode and cathode compartments. The anode chamber was used for bacterial growth that was taken from Akkaya Dam slime, was fed with molasses medium at 5 days intervals. The OD values were determined with a spectrophotometer at 600 nm, COD values were determined with the standard method and wet-dry weight also determined as a function of the incubation period. © 2020 Yildiz Technical University. All rights reserved.