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    Effects of melatonin on testis histology, oxidative stress and spermatogenesis after experimental testis ischemia-reperfusion in rats
    (VERDUCI PUBLISHER, 2012) Koksal, M.; Oguz, E.; Baba, E.; Eren, M. Ali; Ciftci, H.; Demir, M. E.; Ulas, T.
    Background: Testicular torsion due to oxidative stress results in infertility and testicular damage which can be preventable an important health problem worldwide. Aim: The purpose of the present study was to investigate the changes of malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS) levels; histopathological alterations; morphology, concentration and motilities of the sperm in post ischemic reperfused (I/R) testis tissue. Materials and Methods: Forty adult male Wistar rats were carried out and were randomized to five groups; (1) Control group, (2) Ipsilateral left testis ischemia, (3) Melatonin plus ipsilateral left testis ischemia, (4) Contra lateral right testis ischemia, 5. Melatonin plus contralateral right testis ischemia. After 1 h ischemia and 24 h perfusion; MDA, TAS and TOS levels were measured, histopathological alterations were determined using by Johnsen's score (JS) and sperm morphology, concentration, motility were examined. Results: MDA,TAS and TOS levels of the testis tissue did not change in all groups (p > 0.05 for all). JS was decreased in I/R group and melatonin treatment reversed histopathological changes and increased JS both in ipsilateral and contralateral testis. Abnormal sperm rate significantly increased in I/R group and melatonin administration changed abnormal sperm rate to normal. Conclusions: As a result, the present study demonstrated that testicular damage occurs following I/R without an increase of MDA, TAS and TOS levels. Our results also suggested that melatonin is a potent antioxidant agent in preventing testicular I/R injury, as shown by increased JS and changed abnormal sperm rate.
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    The usability of MCP-1, fetuin-A, TAS, and TOS levels in the diagnosis of acute myocardial infarction
    (Verduci Publisher, 2023) Ciftci, H.; Gul, H. F.; Canacik, O.; Dolanbay, T.; Karsli, E.; Ercin, D.; Sahin, L.
    OBJECTIVE: Our aims were to determine whether the levels of plasma mono-cyte chemotactic protein-1 (MCP-1), fetuin-A, se-rum total antioxidant status (TAS), and serum to-tal oxidant status (TOS) are cardiac biomarkers and to clarify their relationship with each other in acute myocardial infarction (AMI).PATIENTS AND METHODS: The study includ-ed 90 participants: 60 patients with AMI [30 with and 30 without ST-segment elevation myocardial infarction (STEMI)] and 30 cardiac patients with-out AMI. The diagnostic values of serum Hs-cTnT, MCP-1, fetuin-A, TAS, and TOS levels in predict-ing AMI were evaluated statistically.RESULTS: Median levels of MCP-1 [120.10 ng/L (interquartile range: 76.94-230.54 ng/L)] and TOS [2.89 U/MI (IQR: 2.31-3.94 U/Ml)] were statistically higher, and median levels of fetu-in-A [433.52 mg/L (IQR: 387.89-584.49 mg/L)] and TAS (3.10 & PLUSMN; 0.86 U/mL) were lower in pa-tients with AMI than in controls. The parameter with the area under the curve (0.815), sensitivity (73.3%), and specificity (66.7%) closest to those of Hs-cTnT was fetuin-A, followed by MCP-1, TOS, and TAS, respectively. A one-unit increase in MCP-1 levels increased the probability of AMI by 1.023 times (p = 0.002). A one-unit increase in fetuin-A levels decreased the probability of AMI by 0.995 times (p = 0.003). A one-unit increase in serum TOS levels was 1.29 times more char-acteristic of STEMI than of NSTEMI (p = 0.044).CONCLUSIONS: MCP-1, oxidative stress pa-rameters, and fetuin-A might support Hs-cTnT levels in the early diagnosis of AMI. Fetuin-A and MCP-1 levels may be independent risk fac-tors for AMI, whereas TOS could be used to dis-tinguish STEMI from NSTEMI.