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    Effect of the metabolic syndrome on the quality of life and sleep in women
    (Cukurova Univ, Fac Medicine, 2021) Cirpan, Rabiye; Degirmencioglu, Arife Zuhal; Kocaoz, Semra
    Purpose: This study was conducted to determine the metabolic syndrome prevalence in women and evaluate its effect on the quality of life and sleep. Materials and Methods: This descriptive and cross-sectional study was completed with 372 women. Data were collected using a descriptive questionnaire, the Pittsburgh Sleep Quality Index, and the SF 36 Quality of Life Scale.. Results: The metabolic syndrome prevalence in women was 41.9%, according to the International Diabetes Federation diagnostic criteria. The mean scores obtained from the sleep quality index by those with metabolic syndrome were significantly higher than those without metabolic syndrome. The median scores obtained from the physical function and role difficulty, pain, general health perception, and mental summary sub-dimensions of the SF-36 quality of life scale by the women who were found to have metabolic syndrome were lower than those without metabolic syndrome. Conclusion: Metabolic syndrome was found to be common in women and to affect the quality of life and sleep negatively in women in this study. We, therefore, recommend women to be evaluated in terms of metabolic syndrome at regular intervals and healthcare professionals to provide training and consultancy services to promote healthy living behaviors that could improve their quality of life and sleep.
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    Prevalence of lower urinary tract symptoms and influencing factors in women
    (Cukurova Univ, Fac Medicine, 2021) Degirmencioglu, Arife Zuhal; Kocaoz, Semra; Cirpan, Rabiye
    Purpose: This study was conducted to determine the prevalence of LUTS in women and the influencing risk factors. Materials and Methods: This cross-sectional study was conducted with 377 women who presented to the internal medicine outpatient departments of a training and research hospital for examination. The data were collected with a questionnaire form and the Bristol Female Lower Urinary Tract Symptoms-Short Form (BFLUTS-SF). Results: The prevalence of at least one LUTS in women was 92.3%. A statistically significant relationship was found between the menopausal status, chronic cough, stress urinary incontinence (SUI) presence in the mother or sister, the presence of a large baby and SUI in a previous pregnancy, and the BFLUTS-SF total scores. Conclusion: We found that storage-related symptoms were most common in these women, and LUTS affected the sexual life and quality of life negatively. Therefore, it is necessary to increase the sensitivity of health professionals to this issue, and to raise the awareness of women about the risk factors, prevention, diagnosis and treatment of LUTS with future training.
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    The levels of anxiety, depression and alexithymia in individuals diagnosed with diabetes and the affecting factors
    (Klinik Psikiyatri Dergisi, 2021) Degirmencioglu, Arife Zuhal; Arabaci, Leyla Baysan; Beser, Nalan Gordeles
    Objective: This study aims to determine the levels of anxiety, depression and alexithymia in individuals diagnosed with diabetes and the affecting factors. Method: The study consisted of 208 patients aged 18 and over diagnosed with diabetes that have been receiving relevant treatment for at least 6 months and had no other chronic diseases. The patients had been registered in the internal medicine outpatient department of a training and research hospital for follow-up between January 15 and June 30, 2018 and had agreed to participate in the study. Results: In the study 61.1% of the patients were females, 57.7% were between 45-64 years old and 81.3% were married. A moderate-level of anxiety and alexithymia as well as a low-level of depression were found in the patients who reported adverse changes in their lives following the diagnosis of diabetes. A statistically significant relationship was found between the levels of anxiety, depression and alexithymia in the patients (p<0.001). Discussion: Patients diagnosed with diabetes should be regularly assessed for psychological distress such as anxiety, depression and alexithymia, as well as physical symptoms. Health professionals, especially nurses should support diabetic patients in developing strategies to cope with and manage these health problems.
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    The role of toll-like receptors in the protective effect of melatonin against doxorubicin-induced pancreatic beta cell toxicity
    (Pergamon-Elsevier Science Ltd, 2019) Taskin, Eylem; Guven, Celal; Kaya, Salih Tunc; Sahin, Leyla; Kocahan, Sayad; Degirmencioglu, Arife Zuhal; Gur, Fatih Mehmet
    Aims: Doxorubicin, an anticancer drug, has a toxic effect on many tissues such as heart, pancreas, liver, kidney, and testis. The aim of current study is to investigate whether melatonin would be protective in doxorubicin-induced beta (beta) cell toxicity via HMGB1/TLR2/TLR4/MAPK/NF-kappa B signaling pathway. Main methods: Human pancreatic beta cell (1.1B4) was used in the present study. Four experimental groups were created as control, melatonin (10 mu M), doxorubicin (2 mu M) and the combination of melatonin with doxorubicin. Following 24-h treatment, Mitogen-activated protein kinase (MAPKs), Toll like receptors (TLRs) including TLR2 and TLR4, pro-and anti-apoptotic protein expression levels were determined by western blotting. Total antioxidant (TAS), oxidant status (TOS) and oxidative stress index (OSI) of the cells as well as superoxide dismutase (SOD) levels were determined. Active caspase-8 activity was measured and TUNEL staining was performed to study apoptotic pathways. Mitochondrial membrane potential (MMP), some protein expressions and F-actin distribution were analyzed. Key findings: Doxorubicin caused to depolarize MMP, resulting in enhancing apoptosis by activation of caspase-8 via MAPKs/NF-kappa B pathway via elevation of TOS and decreasing TAS. Also, doxorubicin destroyed F-actin distribution and elevated TLR2 and some apoptotic proteins, including Bax. However, co-treatment of melatonin with doxorubicin could reverse depolarization of MMP and inhibition of apoptosis through MAPK/NF-kappa B signaling by decreasing TOS and increasing TAS. The co-treatment reversed the alternations of TLR2, TLR4, MAPKs and apoptotic protein expressions induced by doxorubicin. Significance: Melatonin could be a good candidate against pancreatic beta cell toxicity-induced by doxorubicin through TLR2/TLR4/MAPK/NF-kappa B pathways.