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Öğe Association of IL-1Ra and IL-4 Gene VNTRs with Susceptibility to Prostate Cancer in Turkish Population(Allerton Press Inc, 2020) Bingol, G.; Polat, F.; Diler, S. B.Prostate cancer (PCa) is a very common type of cancer among men. It was revealed that Interleukin-4 (IL-4) and interleukin-1 receptor antagonist (IL-1Ra) genes had important functions such as development of prostate cells or regulating the inflammatory processes. The important role of cytokines in inflammatory mechanisms leads to the possibility that polymorphisms of these genes may contribute to the formation of prostate cancer. In this study, we aimed to investigate the association of variable number tandem repeat (VNTR) polymorphisms in the IL-1Ra and IL-4 genes with PCa in Turkish population. 70 prostate cancer patients and 110 healthy controls were involved in a case-control study. Genotype distributions and allele frequencies for the IL-1Ra intron 2 (rs2234663) and IL-4 intron 3 (rs79071878) VNTR polymorphisms were analyzed by using PCR technique. No statistically significant association was identified for both IL-1Ra intron 2 and IL-4 intron 3 polymorphisms between PCa patients and controls (P > 0.05). IL-1Ra intron 2 and IL-4 intron-3 VNTR polymorphisms were not found to be risk factors in prostate cancer and its development in Turkish population.Öğe Association of IL-1Ra and IL-4 Gene VNTRs with Susceptibility to Prostate Cancer in Turkish Population (vol 54, pg 487, 2020)(Allerton Press Inc, 2021) Bingol, G.; Polat, F.; Diler, S. B.An Erratum to this paper has been published: https://doi.org/10.3103/S0095452721010060Öğe Association of MYNN, TERT and TERC Gene Polymorphisms with Prostate Cancer in Turkish Population(Pleiades Publishing Inc, 2020) Polat, F.; Diler, S. B.; Bingol, G.This study aims to determine whether there is any relationship between prostate cancer development and MYNN rs10 936 599, TERC rs2 293 607 and hTERT MNS16A polymorphisms in Turkish population. The research was comprised of 77 individuals with prostate cancer and 116 healthy individuals without history of cancer. Genotyping analysis was performed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The results obtained were evaluated using the chi-square test and unconditional logistic regression analysis. In the study, the GG genotype of TERC rs2293607 polymorphism, the VNTR-243/243 genotype of TERT MNS16A polymorphism, and allele 243 were found to be statistically significant between the patient and control groups (ORc = 3.250, 95% CI = 1.176-8.980, p(c) = 0.023; ORc = 3.09, 95% CI = 1.238-7.717, p(c) = 0.016; OR = 0.638, 95% CI = 0.416-0.978, p = 0.038). On the other hand, there was no significant relationship between MYNN rs109365999 polymorphism and prostate cancer in Turkish population. In conclusion, the obtained data show that the TERC rs2293607 and TERT MNS16A VNTR-243/243 polymorphisms might be potential risk factors for the development of prostate cancer in Turkish population and might be suggested as prognostic markers.Öğe Synthesis, Characterzation, and Genetoxic Effect of Some Novel Schiff Base-Metal Complexes(Maik Nauka/Interperiodica/Springer, 2020) Demir, I.; Diler, S. B.; Ucan, S. Y.A novel ligand (HL) has been synthesized by condensation of 4-nitro-1-naphthylamine with 2-hydroxy-1-naphthaldehyde, and its complexes with Co(II), Ni(II), Cu(II), and Zn(II) have been prepared and charecterized by spectroscopic methods. The effect of the ligand and its copper complex on chromosome has been tested by two methods, CA and micronucleus.Öğe The T-786C, G894T, and intron 4 VNTR (4a/b) polymorphisms of the endothelial nitric oxide synthase gene in prostate cancer cases(MAIK NAUKA/INTERPERIODICA/SPRINGER, 2016) Diler, S. B.; Oden, A.In previously conducted some studies it has been revealed that nitric oxide (NO) and nitric oxide synthase (NOS) system play a significant role in carcinogenesis. Nitric oxide (NO) is regulated by endothelial nitric oxide synthase (eNOS) enzyme which is one of the isoenzymes of NO synthase (NOS). In this study we have tried to come to a conclusion about whether eNOS gene T-786C, G894T and intron 4 VNTR (4a/b) polymorphisms might be considered as a risk factor causing prostate cancer (PCa) or not. A total of 200 subjects were included in this research. 84 patients with PCa (mean age 70.0 +/- 6.4) and 116 healthy controls (mean age 69.9 +/- 7.5) were recruited in this case-control study. Genomic DNA was extracted using the QIAamp DNA Blood Mini Kit (QIAGEN GmbH, Maryland, USA), according to the manufacturer's guidelines. The T-786C, G894T and intron 4 VNTR (4a/b) polymorphisms were amplified using polymerase chain reation (PCR), detected by restriction fragment length polymorphism (RFLP). For T-786C polymorphism CC genotype [odds ratio (OR): 0.34, 95% confidence interval (CI): 0.15-0.78, P = 0.009)] and allele frequency (OR: 0.631, CI: 0.421-0.946, P = 0.026) is significant for control. In patients with PCa eNOS G894T polymorphism, both GT (OR: 0.069, CI: 0.027-0.174; P = 0.0001) and TT (OR: 0.040, CI: 0.013-0.123; P = 0.0001) genotype distribution, and also T allele frequency (OR: 0.237, CI: 0.155-0.362, P = 0.0001) were considered significant statistically. While genotype distribution for the other polymorphism eNOS, intron 4 VNTR (4a/b), is insignificant statistically, "a" allele frequency was found out to be significant (OR: 2.223, CI: 1.311-3.769, P = 0.003). In this study we indicated that genotype and allele frequencies of eNOS T-786C and G894T polymorphisms are statistically significant in patients with PCa. eNOS T-786C and G894T polymorphisms may be associated with PCa susceptibility in the Turkish population. In contrast, intron 4 VNTR (4a/b) polymorphism may not be related to PCa susceptibility in these patients.
