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    Biochemical parameters and clinical outcomes of carbon monoxide poisoning in special groups: children, pregnant women, and the elderly
    (Verduci Editore s.r.l, 2024) Vural, A.; Dolanbay, T.; Ozçelik, M.; Oztorun, Z.Y.; Ardic, N.; Vural, A.B.; Altay, M.C.
    OBJECTIVE: Carbon monoxide (CO), a toxic gas, poses a significant threat to human health. Children, pregnant women, and elderly individuals are particularly vulnerable to this toxicity. This study aims to evaluate the demographic and clinical characteristics of pediatric, pregnant, and geriatric patients. PATIENTS AND METHODS: The study included pediatric, pregnant, and geriatric patients with a confirmed diagnosis of CO poisoning, excluding those with complete file data and those with carboxyhemoglobin (COHb) levels below 5% (for children and pregnant patients) and 10% (for elderly patients). Patients aged < 18 years, > 65 years, and pregnant patients admitted to the adult and pediatric emergency departments were included in the study; statistical analyses were conducted using SPSS Inc., with a p-value of < 0.05 considered statistically significant. RESULTS: For pediatric patients, a statistically significant difference was observed between the two groups in terms of their main complaints, which were primarily attributed to neurological and general symptoms. A positive correlation was found between follow-up time and several factors, including white blood cell (WBC) count and troponin, lactate, lactate dehydrogenase (LDH), and COHb levels. For pregnant patients, no in-hospital mortality was observed in the patients included in this study. A significant negative correlation was identified between age and both COHb and hemoglobin (Hb) levels. A strong positive correlation was found between the COHb levels and hospital follow-up time. For elderly patients, no significant differences were found between the two treatment modalities. Notably, higher COHb levels on admission were associated with a more fatal in-hospital course, with COHb levels > 40% of all patients requiring intubation. CONCLUSIONS: Vulnerable populations are at increased risk of exposure to CO, and the study results emphasize the necessity of heightened awareness and preventive measures to safeguard these individuals from CO poisoning. © 2024 Verduci Editore s.r.l. All rights reserved.
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    The usability of MCP-1, fetuin-A, TAS, and TOS levels in the diagnosis of acute myocardial infarction
    (Verduci Publisher, 2023) Ciftci, H.; Gul, H. F.; Canacik, O.; Dolanbay, T.; Karsli, E.; Ercin, D.; Sahin, L.
    OBJECTIVE: Our aims were to determine whether the levels of plasma mono-cyte chemotactic protein-1 (MCP-1), fetuin-A, se-rum total antioxidant status (TAS), and serum to-tal oxidant status (TOS) are cardiac biomarkers and to clarify their relationship with each other in acute myocardial infarction (AMI).PATIENTS AND METHODS: The study includ-ed 90 participants: 60 patients with AMI [30 with and 30 without ST-segment elevation myocardial infarction (STEMI)] and 30 cardiac patients with-out AMI. The diagnostic values of serum Hs-cTnT, MCP-1, fetuin-A, TAS, and TOS levels in predict-ing AMI were evaluated statistically.RESULTS: Median levels of MCP-1 [120.10 ng/L (interquartile range: 76.94-230.54 ng/L)] and TOS [2.89 U/MI (IQR: 2.31-3.94 U/Ml)] were statistically higher, and median levels of fetu-in-A [433.52 mg/L (IQR: 387.89-584.49 mg/L)] and TAS (3.10 & PLUSMN; 0.86 U/mL) were lower in pa-tients with AMI than in controls. The parameter with the area under the curve (0.815), sensitivity (73.3%), and specificity (66.7%) closest to those of Hs-cTnT was fetuin-A, followed by MCP-1, TOS, and TAS, respectively. A one-unit increase in MCP-1 levels increased the probability of AMI by 1.023 times (p = 0.002). A one-unit increase in fetuin-A levels decreased the probability of AMI by 0.995 times (p = 0.003). A one-unit increase in serum TOS levels was 1.29 times more char-acteristic of STEMI than of NSTEMI (p = 0.044).CONCLUSIONS: MCP-1, oxidative stress pa-rameters, and fetuin-A might support Hs-cTnT levels in the early diagnosis of AMI. Fetuin-A and MCP-1 levels may be independent risk fac-tors for AMI, whereas TOS could be used to dis-tinguish STEMI from NSTEMI.