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    ANALYSIS OF INTERLEUKIN-17, INTERLEUKIN-23, NEOPTERIN AND NESFATIN-1 LEVELS IN THE SERA OF HASHIMOTO PATIENTS
    (Soc Medical Biochemists Serbia, 2023) Bayraktar, Nihayet; Eren, Mehmet Ali; Bayraktar, Mustafa; Ozturk, Ali; Erdogdu, Hamza
    Background: Hashimoto's thyroiditis (HT) is an autoimmu-ne disorder affecting the thyroid gland and may present as goiter or atrophic thyroiditis that may result in various metabolic and inflammatory disorders. The aim of this study is to determine the changes in serum levels of inter-leukin-17 (IL-17), IL-23, neopterin, and nesfatin-1 para-meters in HT patients and to evaluate the possible relati-onship among these parameters.Methods: 90 HT patients and 30 healthy individuals were included in this study. Demographic data of the patients included in the study were recorded and detailed physical examinations were performed. IL-17, IL-23, neopterin, and nesfatin-1 levels were measured in the serum samples of the participants by the ELISA method.Results: Serum IL-17, IL-23, neopterin, levels were signifi-cantly higher and nesfatin-1 levels were significantly lower in the HT group compared to the control group. Statistically significant differences were observed between all the groups except euthyroid HT versus HT treated with levothyroxine for nesfatin-1 at the 0.05 level.Conclusion: IL-17, IL-23, and neopterin were involved in the etiopathogenesis of HT. Weight gain in HT may due to low nesfatin-1 level rather than throid hormone deficiency. These variables could be used as potential biomarkers in the diagnosis, prognosis and fellow up of HT disease.
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    Analysis of serum cytokine and protective vitamin D levels in severe cases of COVID-19
    (Wiley, 2022) Bayraktar, Nihayet; Turan, Hamdiye; Bayraktar, Mehmet; Ozturk, Ali; Erdogdu, Hamza
    In this study, we investigated the role and relationship between the cytokine profile and protective vitamin D by measuring their serum levels in COVID-19 intensive care unit patients with severe illnesses. A total of 74 patients were included in our study. Patients were divided into two groups. Patients in the COVID-19 group (n = 31) and individuals without a history of serious illness or infection were used as the control group (n = 43). The serum concentrations of interleukin-1 (IL-1), IL-6, IL-10, IL-21, and tumor necrosis factor-alpha (TNF-alpha) were measured by enzyme-linked immunosorbent assays. Levels of serum vitamin D were detected with Liquid chromatography-mass spectrometry methodologies. TNF-alpha, IL-1, IL-6, IL-10, IL-21, and vitamin D levels were measured in all patients. The serum cytokine levels in the COVID-19 patient group were significantly higher (151.59 +/- 56.50, 140.37 +/- 64.32, 249.02 +/- 62.84, 129.04 +/- 31.64, and 123.58 +/- 24.49, respectively) than control groups. Serum vitamin D was also significantly low (6.82 +/- 3.29) in patients in the COVID-19 group than the controls (21.96 +/- 5.39). Regarding the correlation of vitamin D with cytokine levels, it was significantly variable. Our study shows that COVID-19 patients are associated with lower serum vitamin D and higher pro-inflammatory cytokines associated with increased virus presence. Our data provide more evidence of the anti-inflammatory effect of vitamin D on COVID-19 patients and the protective effects of vitamin D on risk were demonstrated.