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    24-year-old Male patient Diagnosed with Intramucosal Signet Ring Cell Gastric Cancer with Molecular Analysis: A Case Report
    (Kare Publ, 2020) Eroglu, Mehtap; Akin Bali, Dilara Fatma; Aktas, Sedef Hande; Kankilic, Teoman
    Stomach cancer is the third leading cause of death among cancer-related deaths in the world. Signet-ring cell carcinoma (SRCC), a type of gastric adenocarcinoma, is frequently diagnosed in people aged fifty or older, and its incidence increases with age, but SRCC is rare in young age groups. In general, this type of cancer is thought to be more aggressive and has a worse prognosis than other types of gastric cancer. However, there are uncertainties about the characteristics and survival outcomes. Since the diagnostic tools used in patients with SRCC have low sensitivity and specificity in diagnosis and prognosis, it is important to support the diagnosis, follow-up of treatment and relapse with molecular genetic biomarkers. The aim in the current case is to see if TP53, which is the most frequently mutated gene in SRCC and NF1, that is expressed as one of the largest genes in the human genome and classified as a tumor suppressor gene, can be used as a prognostic genetic biomarker in the pathogenesis of early SRCCIt is predicted that P53 may be a determinant factor in the pathogenesis of SRCC due to the mutation burden in this case.
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    Executive Functions and Theory of Mind Skills of Sexually Abused Female Adolescents and Their Externalizing and the Internalizing Behavioral Problems
    (Routledge Journals, Taylor & Francis Ltd, 2021) Gundogdu, Ummugulsum; Eroglu, Mehtap
    Sexually abused children (SAC) often experience acute and chronic adverse psychological and physiological effects later in life. This study aims to evaluate psychiatric diagnoses, Executive Functions (EF) and Theory of Mind (ToM) skills deficiencies in sexually abused female adolescents and examine the relation of these deficiencies with externalizing and internalizing behavioral problems. The patient group comprised 42 female adolescents aged 14-18 years (mean = 16.42, standard deviation = 1.01). The Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version, Dokuz Eylul ToM Index and Reading the Mind in the Eyes test were applied. The Behavior Rating Inventory of Executive Function, Strengths and Difficulties Questionnaire, and Kiddo-KINDL were completed by the participants and their families. A total of 57.2% (n = 24) were classified as SAC with internalizing behavior problems (SAC+I), whereas 66.7% (n = 28) comprised the SAC with externalizing behavior problems (SAC+A) subgroup. SAC+I showed deficits in EF and TOM. Some EF skills were found to be statistically weaker in SAC+A. There was no difference between SAC+A and SAC-A in the TOM tests. The results highlight the need to explore whether these deficiencies are due to psychiatric diseases or whether those who have disabilities in this field carry a higher risk of psychiatric disorder.
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    Peer bullying among children with autism spectrum disorder in formal education settings: Data from Turkey
    (Elsevier Sci Ltd, 2020) Eroglu, Mehtap; Kilic, Birim Gunay
    Background: Children with an autism spectrum disorder (ASD) may be vulnerable to social isolation and bullying victimisation. We investigated frequency and types of bullying and its as- Autism spectrum disorders sociation with severity of ASD. Method: We compared bullying victimisation and perpetration levels between children with ASD (n = 45), those with mild intellectual disability (ID) (n = 40) and typically-developing (TD) Intellectual disability children (n = 46). Children receiving formal education as inclusive students in primary or secondary schools in Ankara were included in the ASD and ID groups. Results: Both the ASD and ID groups experienced more victimisation through verbal and emotional bullying than the TD group. There was no significant difference in the frequency of bullying perpetration between the groups. All groups were victimised mostly by their own male classmates and in the absence of their teacher from the classroom. There was a positive correlation between bullying victimisation and severity of ASD. Conclusions: Teachers, parents, and physicians should take responsibility to protect children with special needs against peer bullying, as their risk for peer bullying is higher than for TD children.
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    Sensory profiles, behavioral problems, and auditory findings in children with autism spectrum disorder
    (Taylor & Francis Ltd, 2023) Gundogdu, Ummugulsum; Aksoy, Ahmet; Eroglu, Mehtap
    Objective: This study examined the relationship between sensory processing (SP) differences and behavioral problems in children with autism spectrum disorder (ASD). We also investigated whether audiological test results could objectively detect auditory processing differences.Method: Forty-six children with ASD, ages 3-9 years, were enrolled in the study. Problematic behaviors and sensory processing of children were assessed using scales. The otolaryngologist performed a detailed head and neck examination and a formal audiological examination was performed by an audiologist.Results: Stereotypy, hyperactivity, and irritability were related to sensation seeking. Stereotypy was also associated with visual processing. Touch processing differences was related to irritability and inappropriate speech. Lethargy was associated with auditory processing. There were no differences in SP and behavior problems in the children whose audiological profiles could be measured between those who passed or failed the test.Conclusion: There was an association between SP differences and behavioral problems in children with ASD, supporting previous studies. Audiological test results did not reveal the SP differences documented in the parent forms.
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    Surgical treatment of a calcified amorphous tumor originating from left atrium
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2019) Eroglu, Mehtap; Bozguney, Muhammet; Eroglu, Tamer; Acikgoz, Burak
    Calcified amorphous tumor is a non-neoplastic tumor or intracavitary cardiac mass which is rarely seen in heart. It is frequently associated with left ventricle and mitral valve. Clinical symptoms varies from asymptomatic status to serious neurological and cardiopulmonary symptoms. Imaging studies such as echocardiography, computed tomography, or magnetic resonance imaging can reveal the mass preoperatively, although the exact diagnosis is done by pathological inspection of the specimen. Follow-up is recommended by echocardiography after surgical treatment due to its recurrence potential. Herein, we present a mass attached to the mitral valve posterior leaflet causing rather silent symptoms such as dyspnea and fatigue on exertion.
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    The relationship between dissociation symptoms, sleep disturbances, problematic internet use and online gaming in adolescents
    (Routledge Journals, Taylor & Francis Ltd, 2022) Gundogdu, Ummugulsum; Eroglu, Mehtap
    Some adolescents admitted to the child and adolescent psychiatry outpatient clinic experience dissociative symptoms, such as hearing strange sounds, temporary blackouts, seeing images, changes in body parts, and looking at themselves from outside themselves. Some may also have sleep disturbances and a history of spending a long time on the internet. This study investigated the relationship between dissociative symptoms and sleep disorders, problematic internet usage (PIU),aggression and digital game addiction in adolescents. Participants completed the State-Trait Anger Expression Inventory (STAXI), Problematic Internet Usage Scale (PIUS), Digital Game Addiction Scale (DGAS-7), Children's Depression Inventory (CDI), Adolescent Dissociative Experiences Scale (A-DES), Pittsburgh Sleep Quality Index (PSQI), Screen for Child Anxiety Related Emotional Disorders Child Version (SCARED), and a sociodemographic form. Regression analyses were performed to identify associations. The sample consisted of 244 adolescents between 14 and 18 years of age (M = 15.93, SD = 0.90), of which 171 (70.1%) were girls and 73 (29.9%) were boys. Fifty-two (21.3%) were classified as having problematic online gaming (POG+), whereas 192 (78.7%) were classified as not having problematic online gaming (POG-). There was a difference between the two groups in all sub-dimensions of the PIUS, STAXI, CDI, and A-DES. Adolescents who had higher scores on the A-DES had a higher risk of sleep disorders and had higher scores on the PIU, CDI, and SCARED. The POG+ group dissociation scores were considerably higher than POG- group scores. Adolescents with high A-DES scores also had higher anger scores and weaker anger control skills. Consequently, sleep disorders, PIU, and POG may increase dissociative symptoms.