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    Comparison of anatomical and functional outcomes of pars plana vitrectomy for rhegmatogenous retinal detachment with phaco-vitrectomy
    (Gazi Eye Foundation, 2024) Tanriverdi, Abdulbaki; Ozer, Omer; Eroz, Pinar; Dinc, Erdem; Dursun, Ozer; Adiguzel, Ufuk
    Purpose: The aim of the present study was to compare the anatomical and functional outcomes in patients who underwent pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RD) with those who underwent cataract surgery combined with PPV. Materials and Methods: A total of 159 eyes of 159 patients who presented to our outpatient clinic with the complaint of vision loss and underwent surgery with the diagnosis of rhegmatogenous RD were included in this study. Patients who underwent 23 gauge PPV combined with standard cataract surgery were included in group 1 (n=62) and patients who underwent 23 gauge PPV alone were included in group 2 (n=97). Demographic data, preoperative and postoperative best corrected visual acuity (BCVA), anatomical success rates, optical coherence tomography findings and complications were recorded. Results: The median BCVA value before surgery was 0.003 in group 1 and 0.016 in group 2 and the difference was not significant (p=0.69). After surgery, the median visual acuity value in both groups was 0.3 and the increase was significant in both groups (p<0.001 for both groups). Similarly, the postoperative manifest spherical equivalents were similar between the two groups and there was no statistically significant difference (p=0.92). Reoperation was required in 4 patients (6.5%) in group 1 and 15 patients (15.5%) in group 2 due to recurrent detachment and there was no significant difference between the two groups in terms of reoperation rates (p=0.087). Conclusion: Combined surgery in the treatment of rhegmatogenous RD can be safely performed without serious complications. © 2024 The author(s).
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    Comparison of the Cosmetic Efficacy of Extractum Cepae and Silicone-Based Gel in Upper Blepharoplasty
    (Lippincott Williams & Wilkins, 2024) Guclu, Emin Serbulent; Ozer, Omer; Celik, Seda; Eroz, Pinar; Baysal, Zeki
    Background:Upper eyelid blepharoplasty is one of the most common surgeries performed worldwide. However, an important problem after surgery is scar formation. The authors aimed to compare the efficacy of extractum cepae and silicone-based gels on postoperative scar appearance in patients undergoing upper eyelid blepharoplasty.Methods:After suture removal, patients were divided into 3 groups: group 1 [n=82, extractum cepae, sodium heparin, and allantoin mixture, Contractubex Gel (Merz Pharmaceuticals, Frankfurt, Germany)], group 2 [n=81, silicone-based gel (Dermatix Ultra Silicone Gel, Menarini, Singapore)], and group 3 (n=77, no additional treatment). Patients used the topical gels twice daily. All evaluations were performed on color photographs by 2 physicians during the postoperative first and third months.Results:The mean visual analog scale scores were significantly higher in all 3 groups in the postoperative first month (4.39 +/- 2.03, 4.41 +/- 2.57, and 4.33 +/- 2.46, respectively) compared with the postoperative third month (2.22 +/- 1.24, 2.15 +/- 1.38, and 2.29 +/- 1.47, respectively) (P=0.014, 0.037, and 0.026, respectively). The Is the scar more stiff score was higher in the postoperative first month compared with the third month.Conclusions:In conclusion, blepharoplasty scars improved up to the postoperative third month, but the topical gels used did not significantly improve the cosmetic appearance of blepharoplasty scars compared with the control group.
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    Evaluation of Depression Levels in Patients With Primary Open-Angle Glaucoma Using the Geriatric Depression Scale
    (Springernature, 2024) Ozer, Ayseguel Barak; Eroz, Pinar
    Introduction Glaucoma is a chronic disease that can lead to severe visual impairment and blindness. Methods The study included 91 primary open-angle glaucoma patients aged 60 years and older (group 1) and 83 healthy controls (group 2) with similar age and gender distribution. The duration of the disease, the number of anti-glaucomatous drops used daily, and visual field parameters were recorded. All participants then underwent a comprehensive mental status examination by a psychiatrist and were administered the Geriatric Depression Scale (GDS). Results In Group 1, the mean duration of glaucoma was 10.2 +/- 6.0 years, and the mean number of drops used per day was 2.91 +/- 1.47 drops/day. According to visual field (24-2) data, the mean mean deviation (MD) was-7.76 +/- 4.78 dB and the mean pattern standard deviation (PSD) was 5.14 +/- 2.60 dB. According to the classification based on MD, 33 (36.3%) patients were in the early stage, 36 (39.5%) in the intermediate stage, and 22 (24.2%) in the advanced stage. The mean best-corrected visual acuity (BCVA) was 0.85 +/- 0.38 logMAR in group 1 and 0.34 +/- 0.19 logMAR in group 2. The mean GDS scores were 13.7 +/- 7.23 points in group 1 and 3.61 +/- 1.71 points in group 2. There were statistically significant differences between the groups in terms of BCVA and GDS scores (p=0.039 and p<0.001, respectively). Conclusion In conclusion, it is important that ophthalmologists provide adequate information about glaucoma to prevent the development of depression in patients with glaucoma. This information may protect patients from uncertainty. A multidisciplinary approach in the management of glaucoma, a chronic and vision-threatening disease, can positively affect patients' compliance with follow-up and treatment, increase the quality of healthcare, and improve treatment responses.
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    Evaluation of peripheral blood inflammatory biomarkers in sickle cell disease with and without retinopathy
    (Springer, 2024) Ozer, Omer; Dogan, Levent; Baysal, Zeki; Basir, Hakan; Ciftci, Ali Turker; Eroz, Pinar; Guclu, Emin Serbuelent
    Background The aim of this study was to evaluate the clinical significance of blood-cell associated inflammation markers in patients with sickle cell disease (SCD) and sickle cell retinopathy (SCR). Methods Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), systemic immune inflammation index (SIII), systemic inflammation response index (SIRI), systemic inflammation modulation index (SIMI) and aggregate systemic inflammation index (AISI) were calculated. This study included 45 healthy controls (Group 1) and 100 SCD (Group 2). Patients in Group 2 were then divided into two groups: without SCR (Group 3) and with SCR (Group 4), and patients with SCR (Group 4) were further divided into two groups: non-proliferative sickle cell retinopathy (NPSCR) (Group 5) and proliferative sickle cell retinopathy (PSCR) (Group 6). Results The mean values for NLR, PLR, SIII, SIRI, AISI, and SIMI were significantly higher in Group 2 compared to Group 1 (p = 0.011 for NLR, p = 0.004 for SIII, and p < 0.001 for others). Furthermore, AISI and SIMI parameters demonstrated statistically significant discriminatory power to distinguish Group 5 from Group 6 (p = 0.0016 and p = 0.0006, respectively). Conclusion Given the critical role of inflammatory mechanisms in the pathogenesis of SCD and its related complications, the assessment of blood-cell-associated inflammatory markers may present a pragmatic and advantageous approach to the clinical oversight and therapeutic intervention of SCD.
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    The effect of subretinal recombinant tissue plasminogen activator application for submacular hemorrhage
    (Gazi Eye Foundation, 2024) Ozer, Omer; Dinc, Erdem; Dursun, Ozer; Yilmaz, Emre Can; Turkmen, Ismail; Eroz, Pinar
    Purpose: The aim of the present study was to evaluate the outcomes of subretinal tissue plasminogen activator (r-tPA) injection with pars plana vitrectomy (PPV) in patients with submacular hemorrhage (SMH) extending towards the fovea. Materials and Methods: The study included 10 eyes of 10 patients who underwent subretinal r-tPA injection with 23 G PPV due to SMH extending towards the fovea. Following standard 23 G PPV, r-tPA (Actilyse, 10 mg/mL, Boehringer-Ingelheim, Germany) at a concentration of 25 µg/0.1 ml was injected into the subretinal space with a 41 G needle at a concentration of 0.2-0.3 ml. Subsequently, fluid-air-12% C3F8 exchange was performed and intravitreal 1.25 mg bevacizumab was administered. After surgery, the patient was given appropriate head position according to the bleeding site. Results: The mean age of the patients was 73.9 ± 4.7 years, 4 (40%) were male and 6 (60%) were female. Two patients (20%) developed SMH due to retinal macroaneurysm rupture, while choroidal neovascular membrane was the cause of hemorrhage in 8 patients (80%). Best corrected visual acuity was 2.53 ± 0.49 logMAR preoperatively, 1.28 ± 0.66 at one month, 1.08 ± 0.64 at three months and 1.04 ± 0.62 at six months postoperatively and the difference was significant (p<0.001 for each parameter). Conclusions: In patients with submacular hemorrhage, r-tPA administered subretinally provides significant visual acuity improvement without serious complications. Copyright © 2024 The author(s).