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    Determination of the expression of lymphocyte surface markers and cytokine levels in a mouse model of Plasmodium berghei
    (2009) Dogruman-Al F.; Fidan I.; Kustimur S.; Ceber K.; Imir T.
    This study aimed to determine the changes in lymphocyte surface markers and cytokine profiles during a malarial infection in a mouse model of malaria. Mononuclear cells obtained from the spleens of the mice infected with Plasmodium berghei (P. berghei) were stained with anti-mouse CD3, anti-mouse CD4, anti-mouse CD8, anti-mouse CD 19, anti- mouse CD 152, anti-mouse pan natural killer (NK), anti-mouse CD80 monoclonal antibodies and expression of surface markers was evaluated by flow cytometry. In the serum samples of the mice, the levels of tumor necrosis factor alpha (TNF-?), interferon gamma (IFN-?), transforming growth factor-lbeta (TGF-lß), and interleukin (IL)-4, IL-10, and IL-12 cytokines were determined by ELISA method. The expressions of all the surface markers of lymphocyte evaluated were statistically significantly lower in the infected mice than in the healthy control mice (p<0.05). However, except for the level of TGF-lß, the levels of all the other cytokines evaluated were statistically significantly higher in the infected group than in the control group (p<0.001). No significant differences were determined between the TGF-1ß levels of the study and control groups (p>0.05). In this study, T, B, and NK lymphocyte responses were inhibited and cytokine profiles changed in the course of malarial infection. Thus, interventions to increase the Th l lymphocyte response may be beneficial in the prevention of malarial infection.
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    Forming collaborative links between Turkey and US: International Workshop on Rapid Technologies
    (American Society for Engineering Education, 2010) Fidan I.
    As part of a current NSF-CCLI (Course-Curriculum and Laboratory Improvement) grant project, an extra supplementary grant was given in late 2008 to organize an international workshop on Rapid Technologies. This workshop was held in late September 2009 in Istanbul, Turkey. Over seventy academicians and researchers got together and presented the current trends in rapid manufacturing research, education and industry. In this two-day event, educational and technical papers were presented from American, European and Turkish scholars. Reflections of the first and second day have been received from each attendee with an oral interview, and exit survey has been collected to measure the success of the supplementary project and continuously improve the workshop if it is held in the upcoming years. This paper will report the organization of this workshop, and its over-all planning and findings. © American Society for Engineering Education, 2010.