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    EFFECTS of MELATONIN on ACUTE PANCREATITIS INDUCED by DOXORUBICIN in HUMAN PANCREATIC CELL LINES
    (Wiley, 2017) Guven, C.; Guven, E. Taskin; Sevgiler, Y.
    [Abstract Not Available]
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    EFFECTS of TUMOR NECROSIS FACTOR ALPHA INHIBITION on STREPTOZOTOCIN-INDUCED MITOCHONDRIAL DAMAGE in PANCREATIC ? - CELLS
    (Wiley, 2017) Guven, C.; Guven, E. Taskin; Yazgan, P.; Rezvani, A.; Sevgiler, Y.
    [Abstract Not Available]
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    PREVENTION of DOXORUBICIN-INDUCED CARDIOTOXICITY THROUGH ATP SENSITIVE POTASSIUM CHANNEL OPENING
    (Wiley, 2017) Guven, C.; Guven, E. Taskin; Aydin, O.; Sevgiler, Y.
    [Abstract Not Available]
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    The effect of 900-MHz radiofrequency electromagnetic fields during the adolescence on the histological structure of rat testis and its androgen and estrogen receptors localization
    (Ijrr-Iranian Journal Radiation Res, 2021) Gur, F. M.; Keles, A. Ikinci; Erol, H. S.; Guven, C.; Taskin, E.; Kaya, H.; Gur, H. E.
    Background: Mobile phones as an electronic device which are emitting radiofrequency-electromagnetic field (RF-EMF). In this study was intend to determine the contingent effects of cell phone induced RF-EMF on testicular tissue in adolescence. Materials and Methods: Rats in the RF-EMF group were exposed to 900 MHz RF-EMF, while sham and control rats were not. After the completion of the test steps, the testicular tissues which were rapidly removed from the body of sacrificed rats were examined by using histopathological and biochemical methods. Testicular tissues cut to 5 mu m thickness undergo routine histological procedures. Thus, histopathological evaluation will be completed. Malondialdehyde (MDA), glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) levels in testicular tissues were measured by biochemical methods to determine whether oxidative stress occurred or not. Results: Histopathologic findings were not observed in any of the studied groups. There was also no difference between the groups in terms of localization of androgen and estrogen receptors. The incidence of apoptotic index and TUNEL-positive cells was similar in all three groups. In the RF-EMF group, although the levels of MDA and CAT were significantly higher, GSH levels were lower than the other groups. There was no essential difference between the groups in terms of SOD level. Conclusions: The obtained results of this study showed that exposed to 900 MHz RF-EMF in adolescents caused oxidative stress in the testes, but testicular damage which is caused to oxidative stress is remained too low to be detected by histopathological methods in this study.
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    The effects of leptin on F-actin remodelling in type 1 diabetes
    (Via Medica, 2019) Guven, C.; Taskin, E.; Akcakaya, H.; Nurten, R.
    Background: The aim of the current study is to investigate the effect of leptin on cytoskeleton structures in both in vivo and in vitro model of diabetes. Materials and methods: For in vivo studies, leptin in different doses (240, and 480 mg/kg) was injected to the diabetic rats after 1-week of streptozotocin (STZ, 55 mg/kg) treatment. Leptin levels were analysed in serum, liver; and pancreas samples. Hepatic and pancreatic F- and G-actin expressions were determined by Western blotting. For in vitro studies, hepatic and pancreatic primary cell lines were obtained from the control rats. To these cultures, STZ (15 and 30 mM), leptin (50, 60 and 100 ng/mL), and their combinations were applied for 1, 3, and 4 weeks. After the treatment period, F-actin was visualised by the Alexa-fluor fluorescent dye. Results: Streptozotocin decreased the G-actin in both tissues in vivo. However, leptin caused a dose-dependent increase in G-actin levels while F-actin decreased in both tissues. Moreover; leptin caused the perimembranous condensation of actin filaments and amelioration of F-actin structures in vivo. A dose-dependent corruption of F-actin filament structures was observed in leptin-treated primary cells in vitro, while STZ also caused corruption of these filaments. Co-exposure of STZ and leptin caused the amelioration of F-actin filaments, while the perimembranous condensation was also observed as was in vivo study. Conclusions: Leptin therapy could be a candidate for diabetes, but it should not be ruled out as being important the severity of diabetes and leptin doses.