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    Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome
    (C M B Assoc, 2021) Tas, Ayca; Hayta, Emrullah; Karadag, Ahmet; Zontul, Cemile; Ozmen, Esma; Aydin, Suleyman; Silig, Yavuz
    Although there is not yet full clarity of the pathogenesis of fibromyalgia syndrome (FM), central sensitization is considered to be responsible. The purpose of this study was to measure the plasma levels of potassium ion channel proteins (human KCNH2, KCNH6 and KCNH7) in FM patients and healthy control subjects. The study sample includes 76 newly diagnosed FM patients and 79 healthy individuals. Venous blood samples were taken to measure the plasma levels of KCNH2, KCNH6 and KCNH7. Pain severity in FM patients was assessed using a visual analog scale (VAS). Bioinformatics analysis was performed using the STRING v 11 Protein interaction tool. Age, gender and body mass index were seen to be similar in both groups. In comparisons between FM and control groups, KCNH2 plasma levels was found to be significantly lower in the FM group. No significant correlation was found between plasma levels of KCNH2, KCNH6 and KCNH7 protein levels and VAS score of patients with FM. The KCNH2 protein had a high homology score with 9 proteins. The plasma levels of KCNH2 FM patients were found to be lower than those of the healthy control subjects, no difference was determined in respect of the plasma levels of KCNH6 and KCNH7. These results may be of use in guiding future studies on the pathogenesis of FM. Copyright: (c) 2021 by the C.M.B. Association. All rights reserved.
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    THE ASSOCIATION BETWEEN PROGNOSIS AND SARCOPENIA ASSESSED BY PSOAS MUSCLE MEASUREMENTS IN ELDERLY MALE PATIENTS WITH COVID-19
    (Gunes Kitabevi Ltd Sti, 2021) Polat, Musa; Salbas, Cigdem Samur; Sari, Sema; Dogan, Mustafa; Cam, Selim; Karadag, Ahmet
    Introduction: Sarcopenia, which is defined as a generalized loss of skeletal muscle mass and function, is an important clinical condition, especially among elderly patients with comorbidities. This study assesses the association between prognosis and sarcopenia assessed by psoas muscle measurements in elderly male patients with coronavirus disease 2019. Materials and Methods: This study included 130 consecutive elderly male patients hospitalized with coronavirus disease 2019. The participants were followed until their time of discharge or death. The psoas muscle crosssectional area, psoas density, and psoas muscle index measurements were performed based on a single-axial computed tomography section at the L2 vertebral corpus. The outcome measurements of the patients were determined as intensive care unit admission and mortality. Results: During the clinical course of these patients, 29.2% (38) were transferred to the intensive care unit, and 13.1% (17) died. The interclass correlation coefficients for the psoas muscle cross-sectional area and density were 0.91 and 0.93, respectively, between observers. Low psoas muscle index is significantly associated with mortality (p = 0.001), and the probability of mortality increases approximately 5-30 times as the psoas muscle index decreases. No factors were identified as being significantly associated with intensive care unit admission. Conclusion: In elderly male patients who are hospitalized due to coronavirus disease 2019, an assessment of the psoas muscle may provide additional information on the prognosis of the disease.