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    The usability of MCP-1, fetuin-A, TAS, and TOS levels in the diagnosis of acute myocardial infarction
    (Verduci Publisher, 2023) Ciftci, H.; Gul, H. F.; Canacik, O.; Dolanbay, T.; Karsli, E.; Ercin, D.; Sahin, L.
    OBJECTIVE: Our aims were to determine whether the levels of plasma mono-cyte chemotactic protein-1 (MCP-1), fetuin-A, se-rum total antioxidant status (TAS), and serum to-tal oxidant status (TOS) are cardiac biomarkers and to clarify their relationship with each other in acute myocardial infarction (AMI).PATIENTS AND METHODS: The study includ-ed 90 participants: 60 patients with AMI [30 with and 30 without ST-segment elevation myocardial infarction (STEMI)] and 30 cardiac patients with-out AMI. The diagnostic values of serum Hs-cTnT, MCP-1, fetuin-A, TAS, and TOS levels in predict-ing AMI were evaluated statistically.RESULTS: Median levels of MCP-1 [120.10 ng/L (interquartile range: 76.94-230.54 ng/L)] and TOS [2.89 U/MI (IQR: 2.31-3.94 U/Ml)] were statistically higher, and median levels of fetu-in-A [433.52 mg/L (IQR: 387.89-584.49 mg/L)] and TAS (3.10 & PLUSMN; 0.86 U/mL) were lower in pa-tients with AMI than in controls. The parameter with the area under the curve (0.815), sensitivity (73.3%), and specificity (66.7%) closest to those of Hs-cTnT was fetuin-A, followed by MCP-1, TOS, and TAS, respectively. A one-unit increase in MCP-1 levels increased the probability of AMI by 1.023 times (p = 0.002). A one-unit increase in fetuin-A levels decreased the probability of AMI by 0.995 times (p = 0.003). A one-unit increase in serum TOS levels was 1.29 times more char-acteristic of STEMI than of NSTEMI (p = 0.044).CONCLUSIONS: MCP-1, oxidative stress pa-rameters, and fetuin-A might support Hs-cTnT levels in the early diagnosis of AMI. Fetuin-A and MCP-1 levels may be independent risk fac-tors for AMI, whereas TOS could be used to dis-tinguish STEMI from NSTEMI.