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Öğe A significant association between rs2295190 polymorphism of the ESR1 gene and fibromyalgia syndrome(C M B Assoc, 2022) Kaydok, Ercan; Ozmen, Esma; Sari, Ismail; Sen Cakiroglu, Gozde; Tas, Ayca; Silig, Yavuz; Hayta, EmrullahFibromyalgia syndrome (FMS) is a multifactorial disease characterized by chronic diffuse pain. Genetic factors are also involved in the etiology. However, there is not enough information on the genetic factors that play a role in the pathogenesis of FMS. This study aims to investigate the relationship between estrogen receptor 1 gene (ESRI) 594G>A (rs2228480) and 325C>G (rs2295190) polymorphisms and FMS. A total of 294 women, 146 of who were FMS patients and 148 of whom were healthy controls, were enrolled in the study. The instruments used to collect data from patients included patient follow-up forms, Visual Analog Scale (VAS), and Fibromyalgia Impact Questionnaire (FIQ). Genotyping of ESR1 594G>A and 325C>G polymorphisms in the extracted DNA samples was performed using an RT-PCR device and TaqMan hydrolysis probes. it was found that, for rs2295190 polymorphism, patients with CO and GO genotypes versus CC genotypes showed a decreased risk for FMS (OR: 0.442; 95% CI: 0.234-0.833). But there were no significant differences were found in the genotype distribution of rs2228480 polymorphism between the FMS patients and controls. The intragroup evaluation of FMS patients revealed no significant association between symptoms, pain score, FIQ score, and polymorphisms (p>0.05). We believe that there is a significant association between ESR1 rs2295190 polymorphism and FMS and that this polymorphism may be protective against FMS. However, there is a need for comprehensive studies on different populations to obtain clearer data as well as further studies to elucidate the possible mechanism of association. Copyright: (C) 2022 by the C.M.B. Association. All rights reserved.Öğe Comparison of the caregiver burden of the mothers of children with cerebral palsy and healthy children(2020) Kaydok, Ercan; Solum, Sezin; Cinaroglu, Nesibe SultanThe study aims to compare caregiver burden levels of mothers of children with cerebral palsy (CP) to mothers with healthy children. Methods: Participants comprised 40 mothers of children with CP (Group 1), and controls comprised 40 mothers with healthy children(Group 2). Caregiver burden inventory (CBI), hospital anxiety depression scale (HADS) were applied. The functional status of children with CP was evaluated by the Gross Motor Function Classification System (GMFCS). Secondary problems accompanying CP were also noted. Results: A secondary problem was seen in 75% of children with CP. The caregiver burden (CB) and the frequency of depression among Group 1 mothers were significantly higher than Group 2 mothers (p<0,001). CB was found to be higher in children with CP with poor functional status. The CB of caregivers in children with CP with secondary problems was significantly higher than the mothers of children without secondary problems (p<0.05). Conclusion: CP causes a higher burden on care for mothers than on healthy children, and at the same time, more frequent depression is observed in these mothers. Long-term prospective studies are needed to investigate the possible effects of the time shift in the functional status of patients with CP on the CB.Öğe Determination of the increased risk of developing atrial fibrillation in fibromyalgia syndrome(Bmc, 2020) Akkaya, Hasan; Gunturk, Ertugrul Emre; Kaydok, Ercan; Ozdemir, BetulIntroduction: Atrial fibrillation (AF) is the leading cause of ischemic stroke and is one of the most common arrhythmias. Previous studies have shown that impaired diastolic functions, P wave dispersion (Pd), and prolonged atrial conduction times (ACT) are associated with increased incidence of atrial fibrillation (AF). The aim of this study was to evaluate diastolic functions, Pd, and ACT in fibromyalgia syndrome (FMS) patients to determine whether there is an increase in the risk of developing AF. Methods: The study included a total of 140 female patients (70 FMS group, 70 healthy control group). Pd was evaluated using 12 lead electrocardiography (ECG), and diastolic functions and ACT with echocardiography. The ECG and echocardiographic evaluations were performed by different cardiologists blinded to the clinical information of the subjects. Results: There was no difference between the two groups in laboratory and clinical parameters. Patients with FMS had significantly higher echocardiographic parameters of ACT known as left-sided intra-atrial (13.9 +/- 5.9 vs. 8.1 +/- 1.8, p <0.001), right-sided intra-atrial (21.9 +/- 8.2 vs. 10.4 +/- 3.5, p<0.001) and interatrial [40 (25-64) ms vs. 23 (14-27) ms p<0.001] electromechanical interval (EMI) compared with the control group. Pd was significantly greater in the FMS group compared with the control group [46 (29-62) ms vs. 32 (25-37) ms, p<0.001]. In the FMS group, there was no significant relationship of the echocardiographic parameters of ACT, Pmax and Pd with age, E/A ratio and deceleration time (DT); while all these five parameters were significantly correlated with left atrial dimension, isovolumetric relaxation time (IVRT), fibromyalgia impact questionnaire (FIQ) and visual analogue scale (VAS). There was a strong correlation between FIQ and VAS and echocardiographic parameters of ACT, Pmax and Pd. Conclusions: Impaired diastolic functions, an increase in Pd, and prolongation of ACT were observed in FMS. Current disorders are thought to be associated with an increased risk of AF in FMS. The risk of developing AF increases with the severity of FMS and clinical progression.Öğe Dry eye in chronic stroke patients with hemiplegia: A cross-sectional study(Taylor & Francis Ltd, 2020) Kucuk, Esin Benli; Kucuk, Erkut; Kaydok, Ercan; Zor, Kursad Ramazan; Bicer, Gamze YildirimObjective: Dry eye is reported to be associated with several neurological diseases. The aim of this study is to evaluate the patients with hemiplegia after stroke for dry eye and compare their results with a control group. Materials and methods: Forty-five patients with hemiplegia and 45 individuals as the control group were included in the study. Tear function tests (Schirmer and tear breakup time) and a dry eye questionnaire for dry eye symptoms (ocular surface disease index) were performed and the results of the two groups were compared. Results: Schirmer test results were significantly lower in the post-stroke hemiplegia group compared to the control group (11.3 +/- 8.2 mm and 20.6 +/- 11.6 mm, respectively, p < .001). Tear breakup time results were significantly lower in the post-stroke hemiplegia group compared to the control group (7.9 +/- 3.1 s and 12.1 +/- 4.3 s, respectively, p < .001). Ocular surface disease index scores were not significantly different between hemiplegia and control groups (21.6 +/- 20.0 and 19.8 +/- 13.9, respectively, p = .635). Schirmer scores lower than 10 mm (60% and 30%, p < .001) and tear breakup time results lower than 10 s (65.6% and 28.9%, p < .001) were also higher in the hemiplegia group compared to control group. Conclusion: We found lower Schirmer test and tear breakup time results and similar OSDI scores in hemiplegia patients compared to controls. Hemiplegia patients may have dry eye without typical symptoms. This should be taken into consideration in the follow-up and rehabilitation of post-stroke hemiplegia patients.Öğe Nurses and physiotherapists' knowledge levels on autonomic dysreflexia in a rehabilitation hospital(Taylor & Francis Ltd, 2023) Kaydok, ErcanObjective Autonomic dysreflexia is a clinical syndrome that affects people with spinal cord lesions at or above the sixth thoracic vertebral level (T6). This study aims to determine the level of knowledge about autonomic dysreflexia among nurses and physiotherapists involved in spinal cord rehabilitation. Design Single-center survey study. Setting This was conducted at a rehabilitation hospital. Outcome measure : Autonomic dysreflexia knowledge test. Participants Nurses (N = 36) and physiotherapists (N = 32) working at a local rehabilitation hospital participated in this study. Results In the autonomic dysreflexia knowledge test, the nurses obtained an average score of 6.63 +/- 2.2 and the physiotherapists obtained an average score of 6.87 +/- 1.89; there was no significant difference between the two groups (P > 0.05). Less than 25% of the participants had experience with autonomic dysreflexia and the test scores of the participants with this experience were significantly higher (P < 0.001). Conclusion Similar to previous studies, the knowledge level of autonomic dysreflexia among nurses and physiotherapists working in rehabilitation hospitals was low. We think that there is a need for internationally standardized training programs to increase the knowledge level of autonomic dysreflexia for patients, caregivers, and health professionals.Öğe Serum Irisin Levels and Its Relationship with Spasticity Severity in Chronic Stroke Patients(Thieme Medical Publ Inc, 2022) Kaydok, Ercan; Sari, Ismail; Ersan, Serpil; Kucuk, Esin BenliObjective Irisin is a myokine released from muscles by exercise and it has been shown to be a prognostic indicator in acute stroke patients. However, irisin's relationship with the chronic phase of stroke and spasticity has not been studied yet. We aimed to determine the serum level of irisin to examine its relationship with the functional status and severity of spasticity in patients with chronic stroke, and to compare these with healthy controls. Materials and Methods A total of 70 (35 chronic stroke and 35 control patients) patients were included in the study. The blood serum irisin levels of the patients and the controls were evaluated using enzyme-linked immunosorbent assay method, their functional status was evaluated with the modified Rankin scale (mRS), and spasticity severity using the modified Ashworth scale (MAS). Results The mean serum irisin levels of the stroke and the control groups were 6.20 +/- 2.2 and 5.45 +/- 2.3, respectively, and there was no statistically significant difference ( p > 0.05). No significant correlation was found between the serum level of irisin and the severity of spasticity and functional status, assessed by the mRS in stroke patients. Conclusion These results showed that irisin levels in chronic stroke patients were similar to controls, and there was no relationship between the severity of spasticity and functional status and irisin level.Öğe Short-Term Efficacy Comparison of High-Intensity and Low-Intensity Laser Therapy in the Treatment of Lateral Epicondylitis: A Randomized Double-Blind Clinical Study(Turkish League Against Rheumatism, 2020) Kaydok, Ercan; Ordahan, Banu; Solum, Sezin; Karahan, Ali YavuzObjectives: This study aims to evaluate and compare the short-term efficacies of high-intensity laser therapy (HILT) and low-intensity laser therapy (LILT) in the treatment of lateral epicondylitis (LE). Patients and methods: Sixty patients (16 males, 44 females; mean age 44.2 +/- 9.3 years; range, 18 to 65 years) with unilateral elbow pain were randomized into two groups as 30 patients treated with HILT (9 males and 21 females) and 30 patients treated with LILT (7 males and 23 females). The HILT (1,064 nm) and LILT (904 nm) were administered three times a week for three weeks, and each treatment was combined with an epicondylitis bandage. A visual analog scale (VAS), quick Disabilities of the Arm, Shoulder, and Hand (QDASH) questionnaire, Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36), and hand grip strength test were used to evaluate the patients before and three weeks after treatment. Results: The two groups had similar demographic characteristics, including age, sex, occupation, and body mass index (p>0.05). There were no statistically significant differences between the two groups in terms of the pretreatment VAS, QDASH, hand grip strength, and SF-36 scores ( p>0.05). After three weeks, both groups showed significant improvements in all of the parameters (p<0.05). However, in the HILT group, the QDASH, hand grip strength, and SF-36 physical component summary (PCS) scores showed superior improvement compared to the LILT group (p<0.05). Conclusion: Each treatment modality was found to be effective and safe for the short-term treatment of LE. However, the HILT exhibited more significant effects on the hand grip strength, QDASH, and SF-36 PCS scores than the LILT.Öğe The effect of high-intensity versus low-level laser therapy in the management of plantar fasciitis: a randomized clinical trial(Springer London Ltd, 2018) Ordahan, Banu; Karahan, Ali Yavuz; Kaydok, ErcanWe aimed to compare the efficacy of low-level laser therapy (LLLT) and high-intensity laser therapy (HILT) in the treatment of plantar fasciitis (PF). Seventy patients were randomized into either the LLLT (8 men, 27 women; mean age 48.65 +/- 10.81 years) or HILT (7 men, 28 women; mean age 48.73 +/- 11.41 years) groups. LLLT (904 nm) and HILT (1064 nm) were performed three times per week, over a period of 3 weeks. Each treatment combined with silicone insole and stretching exercises. Patients' pain and functional status were evaluated with Visual Analog Scale, Heel Tenderness Index, and Foot and Ankle Outcome Score before and after treatment. A chi-square test was performed to compare demographic and clinical characteristics. Within-group and between-group differences were also investigated. Paired samples t test was used to analyze the differences between baseline and after treatment values, while independent samples t test was used to compare the two groups. Both groups contained similar demographic characteristics including age, sex, and body mass index (all p > 0.05). Three and two patients in the HILT and LLLT group, respectively, were lost to follow-up. At the study onset, there were no statistically significant differences between the two groups in the Visual Analog Scale, Heel Tenderness Index, and Foot And Ankle Outcome Scores. Three weeks later, both groups showed significant improvement in all parameters (p < 0.05). The HILT group demonstrated better improvement in all parameters than the LLLT group. Although both treatments improved the pain levels, function, and quality of life in patients with PF, HILT had a more significant effect than LLLT.Öğe The Effect of Pregabalin on Weight Gain, Balance, Gait,Fatigue and Sleepiness in Patients with Fibromyalgia(2021) Küçük, Esin Benli; Mengi, Gönen; Kaydok, ErcanObjective: Our aim was to evaluate the effect of low dose pregabalin on weight, balance, gait, fatigue, and sleepiness in fibromyalgia patients in a twelve-week follow-up period in this study. Material and Methods: Twenty-eight patients with fibromyalgia diagnosis were included in the study. All patients used 150 mg/day pregabalin during the study period and they were followed for twelve weeks. Weight, body mass index measurements, Tinetti Balance and Gait Test, Epworth Sleepiness Scale, and Fatigue Severity Scale were performed prior to the treatment, at the fourth week, and at the twelfth week of the study. The results at these time points were compared. Results: Among 28 patients who accepted to participate in the study, 11 patients dropped out of the study. Seven of these patients dropped out due to adverse effects. The weight significantly increased at the 4th (p=0.010) and 12th weeks of treatment (p=0.008) compared to the pretreatment measurements. The mean weight gain was 1.5±1.8 kg at the 4th week and 1.7±1.9 kg at the 12th week compared to the baseline. There were no statistically significant differences in the parameters of the Tinetti Balance Test, Tinetti Gait Test, Epworth Sleepiness Scale, and Fatigue Severity Scale scores before and after the treatment periods. Conclusion: Low dose pregabalin induces weight gain in patients with fibromyalgia. Pregabalin does not have a significant effect on gait, balance, sleepiness, and fatigue
