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Öğe Exposure to electromagnetic field, cell phone use behaviors, SAR values, and changes in health following exposure in adolescent university students(Assoc Arquivos Neuro- Psiquiatria, 2021) Keles, Ayse Ikinci; Sahin, Ceyda UzunBackground: The use of technological devices is growing rapidly, and the use of cell phones increases in parallel. Dependence on technological devices is a particular factor in this increased exposure. Many studies have been performed on this electromagnetic field, but no definite conclusions have been drawn. Objective: The purpose of this research was to investigate exposure to electromagnetic field, cell phone use behaviors, the specific absorption rate (SAR) values, and changes in health occurring after exposure in university students. Methods: A questionnaire was administered to 1,019 volunteer students aged 18-24 years at the Nigde Omer Halisdemir and Recep Tayip Erdogan Universities in 2018-2019. The questions were based on a survey of the literature. Results: The students spent an average 4-8 hours per day on their cell phones, and findings such as headache (p=0.002), concentration deficit (p=0.001), tiredness on waking in the morning ( p=0.001), hyperactivity (p=0.001), general feeling of fatigue (p=0.001), and lethargy (p=0.001) increased in a statistically significant manner with length of use. Conclusions: Participants exhibited high levels of cell phone use and experienced biological, behavioral, and sleep problems. They also had very little knowledge about specific SAR values, an important criterion concerning cell phones.Öğe Histopathological and epigenetic alterations in the spinal cord due to prenatal electromagnetic field exposure: An H3K27me3-related mechanism(Sage Publications Inc, 2021) Keles, Ayse Ikinci; Sut, Burcu BitergeNeural system development is one of the most important stages of embryogenesis. Perturbations in this crucial process due to genetic and environmental risk factors cause neural tube defects and other central nervous system diseases. We investigated the effects of prenatal exposure to 900-MHz electromagnetic field (EMF) on the spinal cord. Pregnant rats were exposed to 900-MHz EMF for 1 h/day from E13.5 until birth. Six pups from the control and EMF groups were sacrificed at postnatal day 32, and the upper thoracic region of the spine was removed and processed for histological procedures. For histopathological analyses, hematoxylin&eosin staining and, for stereological analyses and the quantitation of motor neurons, cresyl violet staining was performed. H3K27me3 levels were determined via immunofluorescence staining. Histopathological analysis identified structural alterations of ependymal cells, enlarged central canals, as well as degenerated and shrunken motor neurons in the EMF group, while the control group tissues had normal appearances. We also observed enrichment of H3K27me3 in the ependymal cells and the motor neurons in the spinal cord of the control group rats, while the EMF group had low levels of H3K27me3 staining. Our results suggest that the loss of H3K27me3 signals might correlate with reduced neuronal stem cell potential in the EMF group and result in anatomical and structural differences in the spinal cord. This study provided a comprehensive histopathological analysis of the spinal cord after prenatal EMF exposure and offered an H3K27me3-dependent molecular explanation for the detrimental effects of EMF exposure on the spine.Öğe Morphological changes in the vertebrae and central canal of rat pups born after exposure to the electromagnetic field of pregnant rats(Elsevier Gmbh, 2020) Keles, Ayse IkinciSeveral studies have investigated the effects of the electromagnetic field (EMF) on the central nervous system. However, we encountered no studies of the effects of EMF applied in the prenatal period on the offspring vertebrae. The aim of this study is to investigate the effect of a 900 megahertz (MHz) EMF applied to rat dams in the prenatal period on the vertebrae of rat pups. Female Sprague Dawley rats weighing 180 250 g were used in the experiment. Rats identified as pregnant were divided into two groups, control (n = 3) and EMF (n = 3). No EMF was applied to the control group pregnant rats. EMF was applied to the EMF group rats for 1 h daily on an equal and standard basis on prenatal days 13 21. All newborn rat pups were divided into pup control (n = 6) (PC) and pup EMF (n = 6) (PEMF) groups, and no treatment was performed on either. All animals were decapitated on day 32, and the spinal cord in the upper thoracic region was harvested. Vertebral tissues were subjected to routine histological procedures. Histopathological examination revealed that PEMF group vertebral cartilage had been converted into bone tissue. Comparison of central canal diameter and area values between the PEMF group and the PC group revealed statistically significant increases in the PEMF group (p = 0.000 and p = 0.001, respectively). Statistical analysis revealed no significant difference in mean body weights between the two groups (p > 0.530). Based on these findings, we think that 900 MHz EMF applied in the prenatal period affects the development of the vertebrae. This effect causes pathological changes in the rat pup vertebrae. These findings now raise the question of whether EMF also has an impact on neurological and neurosurgical diseases involving the vertebrae.Öğe The Identification of Intracellular Signalling Pathway Through DHMGB1/TLR2 Axis on Myocardial Ischemia/Reperfusion Injury-Induced Apoptosis(Wiley, 2022) Guven, Eylem Taskin; Guven, Celal; Kaya, Salih Tunc; Keles, Ayse Ikinci; Destegul, Dilek; Pelit, Aykut; Gunay, Ismail[Abstract Not Available]
