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    Relationship between chronic obstructive pulmonary disease and telomerase, agmatine, deubiquitinase and sirtuin in the pathway of aging
    (Bayrakol Medical Publisher, 2023) Kurucay, Deniz; Ozmen, Zeliha Cansel; Seyfikli, Zehra; Ersan, Serpil
    Aim: Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease that has both chronic bronchitis-related changes in airways and differences of emphysema in the lung parenchyma. Aging is a complex and irreversible process involving cells, tissues, organs and systems resulting from numerous endogenous and exogenous factors. Agmatine, telomerase, deubiquitinase and sirtuin molecules appear during aging process. A better understanding of the role of these molecules in aging process may lead to advancing therapies for COPD and comorbidities.In the present study, it was aimed to investigate whether there was a relationship between COPD, a chronic progressive disease, and agmatine, telomerase, sirtuin and deubiquitinase, which are molecules involved in the aging pathway.Material and Methods: Thirty-five patients with COPD and 35 healthy persons without chronic diseases participated in this study. Serum agmatine levels were measured by a fluorescence detector using a high-performance liquid chromatography method (HPLC). Serum Sirtuin, deuibiquitinase and telomerase levels were performed using the ELISA method.Results: A result of the statical analysis in the terms of the deubiquitinase showed no differences between patients and control groups (p>0.05). In the patient group, sirtuin values were lower than in controls (P<005). Telomerase and agmatine values were higher (P<0.05).Discussion: As a result, the increase in telomerase activity may be to prolong the telomere shortening in COPD patients. The increase in agmatine may also be caused by depression and hypoxia in COPD. Decreased sirtuin in COPD can be explained by the increase in aging and inflammation.