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Öğe Evaluation of the Association of Serum Sclerostin and Carotid Intima Media Thickness with Chronic Kidney Failure and Kidney Transplantation(Taiwan Society of Geriatric Emergency and Critical Care Medicine (TSGECM), 2024) Keskiner, Ozlem Oguz; Ozturk, Yasin; Ozer, Hakan; Baloglu, İsmail; Uysal, Saliha; Toker, Aysun; Keskin, SuatPurpose: This study aimed to determine the serum sclerostin levels in kidney transplant recipients, dialysis patients, and patients with non-dialysis chronic kidney disease (CKD), and evaluate their associations with carotid intima-media thickness (CIMT) and carotid artery plaque presence. Methods: The study groups included kidney transplant recipients (n = 61), dialysis patients (n = 43), non-dialysis CKD patients (n = 43), and healthy controls (n = 19). Serum sclerostin levels were measured by the ELISA method. All participants underwent imaging tests for the evaluations of CIMT and carotid plaque presence. Results: Serum sclerostin levels were highest in dialysis patients, followed by the non-dialysis CKD group. Kidney transplant patients and healthy controls had the lowest sclerostin levels. There was a positive correlation between CIMT and sclerostin levels in the CKD group. Sclerostin levels were significantly high in individuals with calcified plaques. Conclusion: The CIMT and serum sclerostin levels of kidney transplant recipients compared to those of CKD patients with and without dialysis may suggest that transplantation may prevent further atherosclerosis, with sclerostin levels promising a predictive role. © 2024, Taiwan Society of Geriatric Emergency & Critical Care Medicine.Öğe Monocyte-HDL Ratio: Can It Be Included in the Follow-Up of Diabetes Mellitus and Diagnosis of Diabetic Nephropathy?(2023) Ozer, Hakan; Aydoğan, Kader Zeybek; Ozturk, Yasin; Yonet, Fethi; Baloglu, IsmailBackground and Aim: Diabetic nephropathy is the most common cause of end-stage renal disease and albuminuria is the earliest manifestation of diabetic nephropathy.Oxidative stress and inflammation caused by advanced glyco-oxidation end products contribute to micro and macrovascular complications of diabetes. Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) is an essential indicator of inflammation and oxidative stress. In this study, we aimed to reveal the relationship between diabetes regulation and complications and MHR. Material and Method: A total of 182 subjects, including 152 patients with diabetes mellitus (DM) and 30 healthy controls, were included in this study. All data of the subjects were scanned retrospectively. The DM group was divided into two groups nephropathy (n=68) and non-nephropathy (n=84), with a limit of 30 mg/day for albuminuria. MHR was calculated by dividing the monocyte count by the HDL cholesterol count. Results: When patients with DM were divided into nephropathy and non-nephropathy, patients with nephropathy had higher MHR levels than the other group. We showed that MHR correlated with albuminuria, creatinine, and HbA1c in patients with diabetic nephropathy. In addition, in the regression analysis, albuminuria and MHR were predictors of DN, while MHR, age, and creatinine were found to be independent predictors of albuminuria. Conclusion: MHR, which is an easily calculated marker with simple laboratory tests, which is frequently requested in routine practice in the follow-up of diabetes patients, can help predict the regulation of diabetes and its kidney complications.Öğe The relationship between FGF23 and anemia in HD and renal transplant patients(Springer, 2022) Baloglu, Ismail; Ozer, Hakan; Ozturk, Yasin; Erdur, Mehmet Fatih; Tonbul, Halil Zeki; Turkmen, KultiginPurpose Recent studies claim that FGF23 is also associated with anemia and inflammation. In this study, the relationship between FGF23 and anemia in hemodialysis (HD) and renal transplantation patients (RTx patients) patients was investigated. Methods This was a cross-sectional study involving 40 RTx patients (13 females, 27 males; mean age, 45.93 +/- 12.49 years) who had transplantation at least 6 months before, 25 HD patients (12 females, 13 males; mean age, 54.72 +/- 15.5 years), and 20 healthy control subjects (13 females, 7 males; mean age, 36.7 +/- 9.38 years). FGF23 was studied using Elisa method. Parameters such as iron, ferritin, total iron binding capacity, and transferrin saturation were assessed. Results FGF23 level was significantly higher in HD patients when compared with the RTx patients and control groups. In the bivariate correlation analysis, hemoglobin was positively correlated with albumin (r = 0.681, p = 0.000), ferritin (r = 0.446, p = 0.043), and negatively correlated with CRP (r = - 0.476, p = 0.016) and FGF23 (r = 0.493, p = 0.043). FGF23 was found to be an independent predictor of decreased hemoglobin in HD patients. In addition, this association was observed to disappear after transplantation. Conclusion While FGF23 is closely related to hemoglobin levels in HD patients, we have shown that this relationship disappears after transplantation.Öğe Two Different Presentation of C3 Glomerulonephritis Treated with Eculizumab: Two Cases and Brief Overview(Aves, 2023) Ozturk, Yasin; Ozer, Hakan; Baloglu, Ismail; Turkmen, KultiginC3 glomerulopathy is a newly defined glomerular disease dominated by C3 complement storage and uncertain C1, C4, and immunoglobin accumulations. Hereditary mutations associated with Complement Factor H (CFH) causing hyperactivation of the alternative complement pathway were identified. Most mutations associated with C3 glomerulopathy are associated with the N-terminal end. Whether mutations are pathogenic or not will direct diagnosis and treatment. We present 2 cases, one 61-year-old and one 24-year-old attending our clinic at different times with hematuria, proteinuria, edema, and kidney failure. Both patients had C3 glomerulopathy diagnosed based on the results of kidney biopsy and were treated with eculizumab. Both cases had CFH-associated mutations.
