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    Ficus benghalensis: A plant with potential pharmacological properties, from tradition to pharmacy
    (Pharmacotherapy Group, 2023) Tahir, Muhammad Mateen; Rasul, Azhar; Riaz, Ammara; Batool, Rabia; Nageen, Bushra; Adnan, Muhammad; Sarfraz, Iqra
    Purpose: To undertake an overview of the potential pharmacological properties of Ficus benghalensisis.Methods: Data were acquired from several online sources, including Scopus, Elsevier Science Direct, PubMed, and Sci-Hub, using the keywords Ficus benghalensis, medicinal plants, anti-oxidant, anti-inflammatory, and anti-cancer.Results: Ficus benghalensis has valuable secondary metabolites including terpenoids, ketones, coumarins, oentacyclic, furocoumarin, flavonols, flavonoids, sterols, esters, carbohydrates, carboxylic acid, and polycyclic aromatic hydrocarbons. Due to its phytochemical profile, it is regarded as a plant with potential pharmacological properties such as anti-diarrheal, anti-inflammatory, anti-cancer, anti-oxidant, anti-bacterial, anti-diabetic, anti-tumor, immunomodulatory, anthelmintic, and anti-angiogenic. This review highlights the phytochemistry, traditional uses and pharmacological potential of Ficus benghalensis.Conclusion: Ficus benghalensis has potentials for treating several ailments. However, further research, including in vivo studies and preclinical trials, is necessary to ascertain its biological and pharmacological uses accurately.
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    Potential Anticancer Properties and Mechanisms of Action of Formononetin
    (Hindawi Ltd, 2019) Jiang, Dongjun; Rasul, Azhar; Batool, Rabia; Sarfraz, Iqra; Hussain, Ghulam; Tahir, Muhammad Mateen; Qin, Tian
    Nature, a vast reservoir of pharmacologically active molecules, has been most promising source of drug leads for the cure of various pathological conditions. Formononetin is one of the bioactive isoflavones isolated from different plants mainly from Trifolium pratense, Glycine max, Sophora flavescens, Pycnanthus angolensis, and Astragalus membranaceus. Formononetin has been well-documented for its anti-inflammatory, anticancer, and antioxidant properties. Recently anticancer activity of formononetin is widely studied. This review aims to highlight the pharmacological potential of formononetin, thus providing an insight of its status in cancer therapeutics. Formononetin fights progression of cancer via inducing apoptosis, arresting cell cycle, and halting metastasis via targeting various pathways which are generally modulated in several cancers. Although reported data acclaims various biological properties of formononetin, further experimentation on mechanism of its action, medicinal chemistry studies, and preclinical investigations are surely needed to figure out full array of its pharmacological and biological potential