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Öğe Identification of immunohistochemical localization of irisin in the dwarf hamster (Phodopus roborovskii) tissues(Wiley, 2018) Gur, F. M.; Timurkaan, S.; Tarakci, B. Gencer; Yalcin, M. H.; Ozkan, Z. E.; Baygeldi, S. B.; Yilmaz, S.Irisin is mainly secreted by heart and skeletal muscle cells. It is an exercise-induced protein that converts white adipose tissue to brown. Increased irisin expression was lead to weight loss and improved glucose tolerance. We investigated irisin immunoreactivity in various tissues of the dwarf hamsters (Phodopus roborovskii). Tissues were processed, embedded in paraffin, sectioned at 5m and stained immunohistochemically for irisin. In the retina, irisin was found almost all layers, except outer nuclear layer. Also, irisin immunoreactivity was observed in the skin, cornea, striated muscle, parotid gland, tongue, oesophagus, stomach and small intestine. The findings from this study support the notion that skeletal muscle is not the primary source of irisin.Öğe Immunohistochemical localization of irisin in mole rats (Spalax leucodon)(Taylor & Francis Inc, 2017) Gur, F. M.; Timurkaan, S.; Yalcin, M. H.; Girgin, A.; Tarakci, B. GencerIrisin was first identified in skeletal muscle cells. It is an exercise protein that is secreted into the circulation; it causes conversion of white adipose tissue to brown adipose tissue. We investigated irisin immunoreactivity in mole rat (Spalax leucodon) tissues. We examined cerebellum, pituitary, heart, liver, pancreas, spleen, uterus, kidney and striated muscle in female adult mole rats. Tissues were processed, embedded in paraffin, sectioned at 5 m and stained immunohistochemically for irisin. Irisin immunostaining was detected in the cytoplasm of stained cells; the cytoplasm of Purkinje cells was unstained. We found that irisin may be synthesized in many tissues. The function of locally synthesized irisin currently is unknown.
