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    Elevated serum S-100B levels in children with temporal lobe epilepsy
    (2013) Calik M.; Abuhandan M.; Sonmezler A.; Kandemir H.; Oz I.; Taskin A.; Iscan A.
    Purpose: An elevated level of S-100B in serum is generally considered to be a biochemical marker of nervous tissue damage. According to our knowledge, no studies have evaluated the serum S-100B protein concentration in children with temporal lobe epilepsy. The objective of this study was to measure the serum levels of S-100B protein in pediatric cases with temporal epilepsy. Methods: This case-controlled cross-sectional study was performed at the Department of Pediatric Neurology, Harran University School of Medicine, Sanliurfa, in Turkey. Serum S-100B protein levels were studied in 19 (12 females, 7 males) children with temporal lobe epilepsy and in 25 (15 females, 10 males) healthy control subjects. Serum samples were collected within 30 min after a complex partial seizure, and serum S-100B protein levels were measured with an electrochemiluminescence immunoassay for the quantification of protein (ECLIA kit, Roche® Diagnostics, Germany). Results: The mean serum concentration of S-100B protein was 0.12 ± 0.02 µg/L in the temporal lobe epilepsy group and 0.07 ± 0.01 µg/L in the control group. The patients showed significantly elevated S-100B protein levels compared with healthy controls (P < 0.001). Conclusion: Our data suggest that increased S-100B protein levels in the serum might reflect neuronal damage in the brains of children with temporal lobe epilepsy. These results do confirm the previous findings of elevated S-100B protein levels in adult patients with temporal lobe epilepsy. © 2012 British Epilepsy Association.