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Evaluation of the relationship between disease severity and the leptin, adiponectin, and chemerin levels in overweight and obese COVID-19 patients
(Bayrakol Medical Publisher, 2024) Seydel, Gonul Seyda; Gunturk, Inayet; Yazici, Cevat; Topaloglu, Ulas Serkan; Eren, Esma Eryilmaz; Yuksel, Recep Civan
Aim: Overweight and obesity are substantial risk factors in the severity of COVID-19 disease. This study aimed to assess the relationship between the disease severity and leptin, adiponectin, and chemerin levels in overweight and obese COVID-19 patients. Material and Methods: The study involved 60 COVID-19 patients (patient group) and 30 healthy controls with BMI >= 25. The patient group was split into two subgroups based on disease severity (30 mild/moderate and 30 severe/critical patients). The levels of leptin, adiponectin, and chemerin in plasma were determined using the ELISA technique. Results: Our study revealed that leptin levels were considerably increased in both groups of COVID-19 patients compared to the healthy controls, while chemerin levels were decreased. In adiponectin levels, there was no statistically significant difference between the groups. Discussion: Plasma leptin and chemerin levels are associated with the progression and/or severity of disease in overweight and obese COVID-19 patients.