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    Evaluation of aortic stiffness parameters in premenopausal migraine patients
    (Cukurova Univ, Fac Medicine, 2020) Gunturk, Ertugrul Emre; Dogan, Selcuk; Topuz, Ayse Nur
    Purpose: Migraine is an episodic primary headache disorder, which affects approximately 10% of the adult population, predominantly females. Based on the changes detected in migraine and previous findings, arterial stiffness can be considered to be an important contributor to vascular events in patients with migraine. The aim of this study was to investigate the associations between atherosclerosis and migraine through the evaluation of aortic stiffness in premenopausal migraine patients. Materials and Methods: The study included 68 female patients with migraine, and a control group of 39 healthy females. To reveal the association between migraine and arterial stiffness, echocardiography was applied and aortic stiffness was evaluated. Blood pressure measurements, basic biochemical tests and the 12 derivation-ECG recordings of each patient were taken simultaneously. Results: Basic echocardiographic findings were similar in patients and the control group. Systolic and diastolic diameters of the aorta, and the change in aortic diameter were also similar in both groups. Aortic distensibility, aortic strain and beta indices were also similar in both groups. No significant differences were determined between patients with and without aura migraine and the control group in respect of systolic blood pressure, diastolic blood pressure and pulse pressure. Conclusion: As a marker of atherosclerosis, the aortic stiffness parameters didn't differ between migraine and control group.
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    Serum interleukin-18 levels are associated with non-dipping pattern in newly diagnosed hypertensive patients
    (Lippincott Williams & Wilkins, 2021) Gunturk, Ertugrul Emre; Gunturk, Inayet; Topuz, Ayse Nur; Akkaya, Hasan; Topuz, Mustafa
    Background Interleukin-18 (IL-18), a pro-inflammatory cytokine, increases inflammation in the endothelium. Increased inflammation plays an important role in the development of hypertension (HT). IL-18 level is higher in hypertensives than normotensives. Objective To investigate the relationship between IL-18 level and diurnal blood pressure (BP) variations in newly diagnosed HT patients. Methods This prospective study included 130 subjects referred to outpatient cardiology clinic with an initial diagnosis of HT. The patients were classified as dipper HT (n = 40), non-dipper HT (n = 50), and normotensive (control, n = 40) according to 24-hour ambulatory BP monitoring. All subjects underwent blood sampling after 12 hours of fasting and transthoracic echocardiography. Results The serum IL-18 level was significantly higher in the patient group compared with the controls (195.17 +/- 93.00 mg/dl vs. 140.75 +/- 71.11 mg/dl, P < 0.01) and also in the non-dipper group than in the dipper group (217.3 +/- 96.90 mg/dl, 167.5 +/- 80.79 mg/dl, P = 0.011). IL-18 level was positively correlated both the night-time SBP and DBP levels (r = 0.29, P = 0.02 and r = 0.34, P < 0.01, respectively). On multivariate linear regression analysis, left atrium diameter, left ventricular mass index, and serum IL-18 level were independent predictors of non-dipping pattern in newly diagnosed HT patients. Conclusion Higher IL-18 level was particularly associated with an increase in the night-time BP levels. IL-18 can be used as a predictor for non-dipper HT in newly diagnosed HT patients.