Yazar "Ucak, I." seçeneğine göre listele

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    Fish processing wastes used as feed ingredient for animal feed and aquaculture feed
    (Green Wave Publishing of Canada, 2020) Afreen, M.; Ucak, I.
    Fish wastes management has become a global problem from the last years. Dispose of seafood wastes cause environmental pollution. To overcome this issue these unwanted seafood products are used for the formation of animal feed and aquaculture feed. These unwanted products include small fish and those parts of fish which are not used as human food. These unwanted parts include viscera, head, fins and skin of fish. These byproducts are rich source of protein, minerals and vitamins so these can be used as a supplement in animal feed. These are also used to fulfill the deficiency of protein in animals. These byproducts can be used in the form of fish meal, fish oil, and protein hydrolysates and fish silage. Protein hydrolysates provide high amount of nitrogen and fish oil provide triglycerides of fatty acids and phospholipids in the animal feed industry. These are also used in the formation of pet feed and in the formation of fertilizers. These byproducts are processed for feeding by using fermentation, biotechnological and bio preservation techniques. © 2020, Green Wave Publishing of Canada. All rights reserved.
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    Signaling networks in TMPRSS2-ERG positive prostate cancers: Do we need a Pied Piper or sharpshooter to deal with at large fused oncoprotein
    (C M B Assoc, 2017) Lin, X.; Qureshi, M. Z.; Romero, M. A.; Yaylim, I.; Arif, S.; Ucak, I.; Fayyaz, S.
    Overwhelmingly increasing scientific evidence has provided near complete resolution of prostate cancer landscape and it is now more understandable that wide ranging factors underlies its development and progression. Increasingly it is being realized that genetic/epigenetic factors, Intra-tumoral and inter-tumoral heterogeneity, loss of apoptosis, dysregulations of spatio-temporally controlled signaling cascades, Darwinian evolution in response to therapeutic pressures play instrumental role in prostate carcinogenesis. Moreover, multi-directional patterns of spread between primary tumors and metastatic sites have also been studied extensively in prostate cancer. Research over the years has gradually and systematically revealed closer association between tumor phenotype and type of gene fusion. Latest developments in deep sequencing technologies have shown that gene fusions originate in a non-random, cell type dependent manner and are much more frequent than previously surmised. These findings enabled sub-classification and categorization of seemingly identical diseases. Furthermore, research methodologies have shown that many gene fusions inform us about risk stratification and many chimeric proteins encoded by the fused genes are being studied as drug target/s. We partition this multi-component review into the molecular basis of formation of fusion transcripts, how protein network is regulated in fusion positive prostate cancer cells and therapeutic strategies which are currently being investigated to efficiently target fusion transcript and its protein product.
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    VEGF mediated signaling in oral cancer
    (C M B Assoc, 2016) Lin, X.; Khalid, S.; Qureshi, M. Z.; Attar, R.; Yaylim, I.; Ucak, I.; Yaqub, A.
    Increasingly it is being realized that oral cancer arises from genetic/epigenetic mutations, dysregulations of spatio-temporally controlled signal transduction cascades and loss of apoptosis. Epidemiological studies have provided a stronger association between tobacco use (chewed and smoked) and oral cancer. Nevertheless, alcohol has also gained attention as a significant risk factor, having a multiplicative synergistic cancer promoting effect with tobacco. Vascular Endothelial Growth Factor (VEGF) mediated signaling has gained limelight because of its instrumental role in endothelial cell proliferation, survival, invasion, migration, chemotaxis of bone marrow (BM)-derived progenitor cells, vasodilation and vascular permeability. In this review we provide most recent updates on involvement of VEGF/VEGFR signaling axis in oral cancer. We partition this multi-component review into different sections and summarize latest advancements related to therapies against VEGF/VEGFR signaling axis and how microRNAs tactfully modulate VEGF and VEGFR in oral cancers. Data obtained through preclinical and clinical studies has revealed that therapeutic benefits associated with VEGF-targeted therapy are complicated in different cancers and involve myriad of mechanisms. A better understanding of VEGF/VEGFR mediated signaling in oral cancers and testing of novel therapeutic agents in preclinical models will prove to be helpful in effective translation of safest drugs from benchtop to the bedside.