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    Evaluation of protective effects of GnRH agonist or antagonist on ovarian reserve with anti-M?llerian hormone and histological analysis in a rat model using cisplatin
    (Termedia Publishing House Ltd, 2023) Tas, Mustafa; Oner, Gokalp; Ulug, Pasa; Yavuz, Adem; Ozcelik, Bulent
    Introduction: The aim of this prospective trial was to evaluate the ovarian reserve with anti-Mullerian hormone (AMH), which is the best predictor of ovarian reserve, and perform histological analysis after exposure to cisplatin with a GnRH agonist or antagonist.Material and methods: Twenty-four Wistar albino rats were randomly divided into three groups, each consisting of eight rats. In the GnRH agonist group (group 1), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg triptorelin. In the GnRH antagonist group (group 2), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg cetrorelix. In the control group (group 3), rats received 50 mg/m2 cisplatin. Ovarian reserve was assessed by AMH and histology.Results: Primary follicle counts were higher in group 2 (4.50 +/- 1.47 vs. 3.50 +/- 1.70 vs. 3.00 +/- 3.54) and secondary follicle counts were higher in group 1 (2.96 +/- 1.11 vs. 1.74 +/- 1.03 vs. 1.37 +/- 3.11). Numbers of tertiary follicles were higher both in groups 1 and 2 than the control group (1.36 +/- 0.83 vs. 0.84 +/- 0.99 vs. 0.50 +/- 0.75). The total follicle count of the study groups were signifi-cantly higher compared with the control group (14.32 +/- 5.96 vs. 12.48 +/- 4.12 vs. 10.63 +/- 6.80). AMH was significantly higher in groups 1 and 2 compared with the control group (18.56 +/- 25.33 vs. 16.48 +/- 24.66 vs. 9.37 +/- 26.54).Conclusions: This is the first prospective randomized controlled study show-ing the protective effects of GnRH agonist and antagonist on ovarian reserve after cisplatin exposure in an animal model.