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    Effects of Allium tuncelianum on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin
    (Ankara Univ Press, 2019) Atila, Gozde; Bilgili, Ali; Uslu, Hamit; Erdag, Dincer; Ozkan, Oktay
    In this study, it was aimed to investigate the effects of Allium tuncelianum extract on hyperglycemia and oxidative stress in the kidney and liver tissues in rats with diabetes mellitus induced by streptozotocin. The rats were randomly divided into 4 groups with 10 animals in each group: Control group (C) was intraperitoneally (i.p.) treated with physiological saline solution, diabetic control (DC) group i.p. with a single dose of 50 mg/kg streptozotocin (STZ), diabetic + insulin (D+I) group i.p. with a single dose of 50 mg/kg STZ and subcutaneously (s.c.) with 2 IU insulin for 28 days (Levemir Flexpen), diabetic + Allium tuncelianum extract (D+AT) group i.p. with a single dose of 50 mg/kg STZ and orally with 250 mg/kg Allium tuncelianum extract for 28 days. The serum glycated hemoglobin (HbA1c), insulin levels and the kidney and liver thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT) activities were determined by using ELISA kits. Increased blood glucose levels (p<0.001), increased TBARS levels (p<0.001, p<0.01 respectively), and decreased SOD and CAT activities (p<0.001) in the kidney and liver tissue homogenates were determined in diabetic control group compared to control group. Allium tuncelianum extract had potent antioxidant activities in the diabetic rats, and demonstrated improvement effects by increasing insulin levels, decreasing glycated hemoglobin levels, and attenuating oxidative stress in the diabetic rats. This study suggests that Allium tuncelianum extract may have therapeutic potential for patients with diabetes.