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Öğe Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments(Taylor & Francis Inc, 2022) Varol, Aysegul; Sezen, Serap; Evcimen, Dilhan; Zarepour, Atefeh; Ulus, Gonul; Zarrabi, Ali; Badr, GamalBee venom therapy is known as a traditional approach to curing many medical conditions such as arthritis, pain and rheumatism. Bee venom also provides promising potential for treating many cancers such as breast, lung, ovary, stomach, kidney, prostate, cervical, colon and esophageal cancers, osteosarcoma, leukemia, melanoma and hepatocellular carcinoma. We therefore focused not only on the molecular activity mechanisms and cellular targets of bee venom and its components, but also on modern solutions as cutting-edge nanotechnological advances to overcome existing bottlenecks, and the latest advances in the anticancer application of bee venom in clinical settings.Öğe Lycopene: Food Sources, Biological Activities, and Human Health Benefits(Hindawi Ltd, 2021) Khan, Usman Mir; Sevindik, Mustafa; Zarrabi, Ali; Nami, Mohammad; Ozdemir, Betul; Kaplan, Dilara Nur; Selamoglu, ZelihaAs an antioxidant, lycopene has acquired importance as it prevents autoxidation of fats and related products. Tomatoes are an important agricultural product that is a great source of lycopene. It contains many vitamins and minerals, fiber, and carbohydrates and is associated with various positive effects on health. The antioxidant potential of tomatoes is substantially explained with lycopene compounds. Diet is a major risk factor for heart diseases which is shown as the most important cause of death in the world. It has been observed that the lycopene taken in the diet has positive effects in many stages of atherosclerosis. The serum lipid levels, endothelial dysfunction, inflammation, blood pressure, and antioxidative potential are mainly affected by lycopene. These natural antioxidants, which can also enhance the nutritional value of foods, may lead to new ways if used in food preservation. In this review study, the antioxidant potential and cardiovascular protection mechanism of lycopene are discussed.